子癎前期患者血清胎盘生长因子的变化及意义

Significance of Serum Placenta Growth Factor Level in Preeclampsia

目的:探讨胎盘生长因子与子癎前期发病的关系。方法:检测40例子癎前期患者及20例正常晚期妊娠血清胎盘生长因子(PlGF)的水平及胎盘CD34表达,计数微血管密度(MVD)。结果:轻度子癎前期组血清PlGF为201.25±52.33pg/ml,胎盘MVD计数为45.6±4.2,重度子癎前期组分别为165.83±37.54pg/ml,40.2±3.9,两组均低于正常晚期妊娠组315.76±76.98pg/ml,58.2±4.8,差异有显著性意义(P<0.05)。结论:子癎前期患者血清PlGF及胎盘MVD显著降低,可能与子癎前期的发病有一定关系。

Objective：To detect the expression of placenta growth factor （PIGF） in matemal pedpheral circulation from normal pregnancy and preeclarnpsia （PE）,and to determine whether placenta growth factor is associated with the pathogenesis of preeclampsia. Methods.The serum PIGF level collected from 40 PE patients and 20 normolen±sive controls was measured by enzyme linked immunoassay （ ELISA）. The placental microvessel was stained with CD54 by immunohistochemistry and the microvessel density （MVD） was counted. Results： The serum PIGF level in mild preeclampsia group （201.25 ± 52.33 pg/ml） and severe preeclampsia group （ 165.83 ± 37.54 pg/ml ） were significantly lower than those from normal pregnancies （315.76 ± 76.98 pg/ml）. The MVD of placental tissues were significantly lower in mild （45.6 ± 4.2 ） and severe （40.2 ± 3.9 ） preeclamlampsia groups than in normal pregnancy group （58.2 ± 4.8）. Conclusions： Decreased expression of serum PIGF and 1the decline of MVD in placental tissues might play an important role in pathogenesis of preeclampsia.