大容量全肺灌洗治疗肺泡蛋白沉积症

目的观察全麻下进行全肺灌洗的安全性与疗效。方法对5例有经纤支镜活检检查或支气管肺泡灌洗病理证实的肺泡蛋白沉积症患者进行分次大容量全肺灌洗术治疗,并观察术中的安全性,比较术前、术后血气分析和肺功能改变。结果5例患者在进行全肺灌洗后症状明显缓解,1例发生胸腔积液,术后血氧分压与血氧饱和度明显提高,肺功能有显著改善。结论全麻下进行全肺大容量灌洗在目前条件下具有高度安全性,是最好的治疗方案。

Objective To observe the safety and effect of large volume whole lung larvage （WLL）. Methods Appling large volume WLL under general anaesthesia to five cases who were diagnosed as pulmonary alveolar proteinosis （PAP） by biopsy through fiber bronchescopy or bronchiol alvemlar lavage, and observing the safety of the treatment, comparing the aterial blood - gas analysis and lung function before and after WLL treatment. Results Five cases all relieved after WLL, one case got pleural effusion. The blood oxygen pressure and saturation increased obviously and lung function improved significantly after the treatment. Conclusion Large volmne WLL treatment under general anaesthesia is safe and could be the best way to treat PAP.