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微波辐射下浓硫酸催化嘧啶酮的无溶剂合成 被引量：1

Synthesis of substituted 3,4-dihydropyrimidin-2(1-H)-ones under microwave irradiation and solvent-free condition catalyzed by sulphuric acid
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摘要 微波辐射下,以浓硫酸为催化剂,芳香醛、尿素和乙酰乙酸乙酯为原料,无溶剂下发生B iginelli缩合反应,高产率地合成了10个3,4二-氢嘧啶-2酮-衍生物。该方法不仅反应条件温和,反应时间短,避免使用昂贵的催化剂,后处理过程简单,而且避免了使用溶剂给环境带来的污染,具有绿色合成的特点。 Ten Substituted 3,4- dihydropyrimidin-2（ 1 -H） -ones were synthesized by three -component one -pot reaction of aromatic aldehydes, ethyl acetoacetate and urea using sulphuric acid as catalyst under microwave irradiation and solvent - free conditious. Advantages of the present method are the excellent yield, operational simplicity and avoidance of the use of solvent.
作者 梁兵 王锡天 王进贤
机构地区 西北师范大学化学化工学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2006年第8期927-930,共4页 Chemical Research and Application
基金 国家自然科学基金资助项目(20272047 20572086) 甘肃省自然科学基金资助项目(3ZS051-A25-001) 甘肃省高分子材料重点实验室基金资助项目
关键词 芳香醛 尿素 乙酰乙酸乙酯 微波 3 4-二氢嘧啶-2-酮衍生物 合成 aryl aldehydes urea ethyl actoacetone microwave substituted 3,4 - dihydropyrimidin - 2 （ 1 - H） - ones green synthesis
分类号 O621.25 [理学—有机化学]
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共引文献43

同被引文献14

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化学研究与应用
2006年 第8期

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