摘要
目的研究电流强度对盐酸丁卡因离子导入凝胶的渗透速率的影响。方法以盐酸丁卡因为模型药物,采用离子导入作为促透方法,分别测定不同电流强度下的盐酸丁卡因离子导入凝胶在离子导入后接受室溶液的吸收度,计算它们的稳态透皮速率。结果电流强度为0.05,0.1,0.15,0.2和0.25mA时,稳态透皮速率分别为10.18,22.94,34.62,41.60和51.35μg/cm2×h。结论在一定的电流强度下,漏槽条件下,盐酸丁卡因离子导入凝胶渗透速率与电流强度有较好的线性关系。
OBJECTIVE To investigate the effect of current on drug transdermal iontophoresis flux of jel. METHODS Tetracaine hydrochloride was employed as model drug, The iontophorefie flux of tetracaine hydroehloride jel through rat skin was investigated using modified Franz one-chamber diffusion ceils. RESULTS When the current strength of iontophoresis was 0.05mA,0.1mA,0. 15 mA, 0.2mA and 0.25 mA, the iontophoretic flux of tetracaine hydrochloride jel were 10.18,22.94,34.62,41.60 and 51.35 （ g/cm^2 × h respectively. CONCLUSION The iontophoretic flux of jel is proportional to the applied current density.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2006年第4期307-308,共2页
Chinese Journal of Modern Applied Pharmacy
基金
浙江省药剂专业委员会医院药学基金资助
关键词
盐酸丁卡因
离子导入
凝胶
电流强度
渗透速率
tetracaine hydrochloride
iontophoresis
jel
current
iontophoretic flux
