糖神胶囊工艺改革及量效关系的实验研究

Experimental study of the new tangshen capsule effect and dosage

目的:比较糖神胶囊普通制剂和不同剂量新工艺制剂的疗效关系。方法:制备链脲佐菌素糖尿病大鼠模型,分别用普通制剂和不同剂量新工艺制剂的糖神胶囊灌胃,观察8周。检测服药前后空腹血糖(FBG)、红细胞中山梨醇(RBCS)的含量、运动神经传导速度(MNCV)、甩尾反射潜伏期(TFL)。结果:与普通制剂相比,新工艺制剂的糖神胶囊可降低链脲佐菌素糖尿病大鼠的FBG、RBCS含量,加快MNCV,延长TFL(P均<0.05)。1/2剂量的新工艺制剂与普通制剂疗效相似。结论:糖神胶囊新工艺制剂可明显提高药效,减少服药剂量。

Objective： To compare the effect of Tangshen capsule＇s normal preparations with new preparations. Methods： Diabetic rat models induced by streptozotocin administered through intragstricinfusion with normal preparations of Tangshen capsule and different dosages of Tangshen capsule made with new technics respectively, were observed for 8 weeks. The fore-and-aft fasting blood glucose （FBG）, content of sorbitol in red cells （RBCS）, conduct velocity of the motor nerve （MNCV） and tail flick latency （TFL） were detected. Results： Compared with the normal preparation, the new technical preparations of the Tangshen capsule could reduce the FBG, RBCS, speed up the MNCV and make the TFL longer（ P 〈 0.05）. Half dosage of the new technical prepartions and full dosage of normal prepartions had the same effect. Conclusion： Tangshen capsule prepared with new technical method markedly improves the effect and reduces dosage of drugs.