亚甲基四氢叶酸还原酶基因多态性与肺癌易感性的关系

Polymorphisms of 5,10-Methylenetetrahydrofolate Reductase and Risk of Lung Cancer in Guangdong Population

目的研究亚甲基四氢叶酸还原酶(MTHFR)基因多态性与肺癌易感性的关系。方法采用PCRRFLP方法检测MTHFR基因型在广东地区肺癌患者和正常人群中的分布。结果肺癌组和对照组中MTHFR各基因型的分布有显著性差异(P=0.030),在男女两种性别之间,非小细胞肺癌和小细胞肺癌之间,非小细胞肺癌各个病理类型之间,肺癌病例各个临床分期之间MTHFRC677T多态性的分布没有显著性差异。结论MTHFR基因C677T突变在肺癌病例中的分布与正常人群中的分布有明显的差异。

Objective To study the relation between polymorphisms of N^5.10-methylenetetrahydrofolate reductase（MTHFR） and susceptibility of lung cancer. Methods We conducted a case control study with 100 cases of lung cancer and 100 population based controls in Guangdong province. MTHFR genotypes were detected by PCR-RFLP method. Results The expressions of MTHFR genotypes have a statistically significant difference between lung cancer and healthy people（P = 0. 030）. And there are on such difference among different gender, pathology types, and clinical stages. Conclusion The prevalence of MTHFR genotypes has a statistically significant difference between lung cancer and healthy people.