摘要
目的研究亚甲基四氢叶酸还原酶(MTHFR)基因多态性与肺癌易感性的关系。方法采用PCRRFLP方法检测MTHFR基因型在广东地区肺癌患者和正常人群中的分布。结果肺癌组和对照组中MTHFR各基因型的分布有显著性差异(P=0.030),在男女两种性别之间,非小细胞肺癌和小细胞肺癌之间,非小细胞肺癌各个病理类型之间,肺癌病例各个临床分期之间MTHFRC677T多态性的分布没有显著性差异。结论MTHFR基因C677T突变在肺癌病例中的分布与正常人群中的分布有明显的差异。
Objective To study the relation between polymorphisms of N^5.10-methylenetetrahydrofolate reductase(MTHFR) and susceptibility of lung cancer. Methods We conducted a case control study with 100 cases of lung cancer and 100 population based controls in Guangdong province. MTHFR genotypes were detected by PCR-RFLP method. Results The expressions of MTHFR genotypes have a statistically significant difference between lung cancer and healthy people(P = 0. 030). And there are on such difference among different gender, pathology types, and clinical stages. Conclusion The prevalence of MTHFR genotypes has a statistically significant difference between lung cancer and healthy people.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第8期572-574,共3页
Cancer Research on Prevention and Treatment
关键词
亚甲基四氢叶酸还原酶
基因多态性
肺癌
Lung cancer
N^5.10- methylenetetrahydrofolate reductase
Gene Polymorphism
Lung Cancer