多发伤患者血清IL-6的变化(附42例分析)

Detection of serum interleukin-6 in multiple trauma patients:Analysis of 42 cases

目的研究多发伤后血清白细胞介素6(IL-6)的变化及其与创伤评分的关系,探讨其临床意义。方法选择多发性创伤患者42例,采用ELISA法测定血清IL-6含量。结果血清IL-6值于创伤后24 h内明显高于正常对照组(P<0.05),动态观察一周,创伤患者呈持续性上升变化,轻度患者血清IL-6含量低于重度、极重度患者,血清IL-6的含量随创伤严重程度增加(P<0.05)。结论IL-6可作为判别创伤严重程度的灵敏指标之一,可能参与了多发性创伤病理生理过程。

Objective To investigate the post-traumatic changes in the serum level of interleukin-6 （IL-6） and their relationship with injury severity score （ISS） and to inquire into the possible mechanism and clinical significance. Methods Fortytwo patients with mechanical trauma were eligibled and included. The serum levels of IL-6 was assayed by ELISA. Results The serum level of IL-6 was significantly higher in patients with trauma than in normal group with in 24 hours （P〈0.05）. The dynamical observation showed that IL-6 demonstrated curve changed with increase in early stage and later. The climax of them appeared earlier in mild group than those in severe and extremely severe groups. The level of IL-6 was correlative with the severity of trauma （P〈0.05）. Conclusion The level of IL-6 is one of sensitive indexes of the degree of trauma. IL-6 may be involved in the pathological processes of multiple injury.