非淋菌性泌尿生殖道感染患者病原体及耐药性分析

Analysis of pathogeny in infection of urinary and reproductive systerm without gonorrhea and its drug resistance to antibiotics

目的比较不同性别患者标本中支原体和衣原体分离率及对9种抗生素的耐药性。方法对1425例疑为非淋菌性泌尿生殖道感染(NGU)患者的泌尿生殖道标本进行支原体和衣原体检测,同时对支原体检测阳性标本进行菌落计数和抗生素敏感性检测。结果1425例标本中支原体和衣原体总分离率为28.2%,其中男性标本中支原体和衣原体分离率为11%,女性标本中支原体和衣原体总分离率为38.7%。Uu菌落计数结果为≥104cfu/ml,女性(32.2%)明显高于男性(7.8%);Mh菌落计数结果≥104cfu/ml,女性(2.3%)与男性(1.1%)基本相同。支原体对九种抗生素的耐药率各不相同,其中强力霉素(DOX)和美满霉素(MIN)具有较高的敏感性。结论NGU患者中支原体和衣原体是主要的病原,监测支原体的耐药性对指导临床治疗具有重要意义,DOX和MIN可作为治疗支原体感染NGU的首选药物。

Objective To compare the infections rate of Ureaplasma urealyticum （Uu）, mycoplasma hominis （Mh） and Chlamydia trachomatis （CT）, and to analysis the drug resistance to nine kinds of antibiotics of Mh and Uu. Methods CT, UU, Mh in genitourinary tract of 1 425 nogonococcal urethritis （NGU） patients was detected. Results In 1 425 tested sampies, 28.2%were mycoplasma and chlamydia positive. In 538 virility tested samples, 11% were mycoplasma and chlamydia positive. In 887 female tested samples. 38. 7 % were mycoplasma and chlamydia positive. In 538 virility tested samples, 7.8 were Uu≥ 10^4cfu/ml, and 1.1% were Mh≥ 10^4cfu/ml. In 887 female tested samples, 32.2% were Uu% 104cfu/ml, and 2.3% were Mh≥10^4cfu/ml. The sensitivity of Mycoplasma to those antimicrobials was ranged from high to low as follows： doxycycline, minocycline, clarithromycin, josamycin, Levofloxacin, Azithrymocin, Sparfloxacin, Ofloxacin, Roxithromycin. Conclusion In genitourinary tract, mycoplasma infection is more than Chlamydia infections. Resistance monitoring of mycoplasma periodically has important significance in clinical drug treatment.