犬颅内压增高肺表面活性物质变化

Changes of Pulmonary Surfactant Associated to Intracranial Hypertension in Dogs

目的：了解颅内压增高后肺表面活性物质（ＰＳ）改变，探讨ＰＳ变化在呼吸功能不全中的作用。方法：采用硬膜外囊注入生理盐水升高犬颅内压至８ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ），测量血气和支气管肺灌洗液（ＢＡＬＦ）物理特性。结果：动脉血氧分压及ＢＡＬＦ最大表面张力（ｒｍａｘ）显著降低，最小表面张力（ｒｍｉｎ）显著增加，滞环面积（ＨＡ）缩小，白蛋白增加，肺含水量增加。结论：颅内压增高后肺表面活性物质减少，ＰＳ测定有助于颅内压增高后呼吸功能损害的早期判断。

Aim: To probe into the changes of pulmonary surfactant (PS) after intracranial hypertension and effect of PS on pulmonary dysfunction. Methods: The intracranial pressure in dogs was raised abruptly to 8 kPa by injecting saline into extradural balloon. Blood gas and physics property of bronchoalveolar lavage fluid (BALF) were measured. Results: Arterial O 2 tension and maximal surface tension decreased significantly. Minimal surface tension increased and hysteresis area (HA) dropped. There was a marked increase of albumin in BALF and lung water. It was proposed that PS was decreased after intracranial hypertension. Conclusion: The determination of PS may serve as an early diagnosis of pulmonary dysfunction after intracranial hypertension.