全军单克隆抗体的研究进展

Advance in Monoclonal Antibody Study in Chinese People Liberation Army

作者概述了近10年军队系统单克隆抗体(McAb)技术研究的进展。军队开展McAb的研究是同国内同步进行的。他们曾采用了各种先进方法,制备出包括抗微生物、肿瘤相关抗原及标志物、白细胞分化抗原、血小板、淋巴因子、各种蛋白、激素及酸等80余种McAb,其中多种抗病毒McAb己制成系多列产品。一些研究已从实验阶段进入军事医学和临床医学的实际应用和基础医学研究的探索,抗病毒和抗肿瘤McAb正在进行广泛的临床诊断和治疗研究,並已取得了效果。文中评述了军队开展杂交瘤枝术的组织领导、技术培训、学术交流的特点及其在全国所起的作用,也讨论了McAb技术发展中的有关问题。

The advances in monoclonal antibody study in Chinese People Liberation Army ( PLA ) over the past ten years have been reviewed. The studies of monoclonal antibody in PLA and the domestic researches almost synchronized. In this field, researchers in PLA have explored and utilized a lot of advanced means and methods, and produced more than 80 McAbs against virus, tumor associated antigen and tumor marker, leucocyte differentiation antigen, Platelet, lymphocyte factor, proteins, hormones, enzymes, etc. of which some antivirus monoclonal antibodies have been made a series of products. Most researches have been converted from the laboratory phase to the practice in military, clinical medical and the probe of basic medical study. The diagnostic and clinical therapy study in anti-virus and tumor monoclonal antibodies is under way and have obtained beneficial results. The features of the organization and leading, technical training, academic exchange and its influence in the whole country have been reviewed. Some problems about the latest developments of monoclonal antibody technique have also been discussed.