摘要
肌萎缩侧索硬化症(ALS)是一种运动神经元的进行性变性疾病。其发病机制未明,目前缺乏特效治疗。我们对近年来药物:抗兴奋性氨基酸毒性、神经营养因子、抗凋亡、抗炎性类药物等治疗ALS的研究进展进行了综述。
出处
《国际神经病学神经外科学杂志》
2006年第4期322-326,共5页
Journal of International Neurology and Neurosurgery
参考文献28
-
1Kalra S,Tai P,Genge A,Arnold DL.Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging.J Neurol,2006 K[Epub ahead of print].
-
2Saroff D,Delfs J,Kumetsov D,et al.Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity.Neuroreport,2000,11(5):117-121.
-
3Kanki R,Nakamizo T,Yamashita H,et al.Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons.Brain Res,2004,1015(1-2):73-81.
-
4Mazzini L,Mora G,Balzarini C,et al.The natural history and the effects of gabapentin in amyotrophic lateral sclerosis.J Neurol Sci,1998,160(Suppl 1):S57-63.
-
5Miller RG,Moore D,Young LA,et al.Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis.WALS Study Group.Western Amyotrophic Lateral Sclerosis Study Group.Neurology,1996,47(6):1383-1388.
-
6Kalra S,Cashman NR,Caramanos Z,et al.Gabapentin therapy for amyotrophic lateral sclerosis:lack of improvement in neuronal integrity shown by MR spectroscopy.AJNR Am J Neuroradiol,2003,24 (3):476-480.
-
7Ryberg H,Askmark H,Persson LI.A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine:effects on CSF glutamate,aspartate,branched-chain amino acid levels and clinical parameters.Acta Neurol Scand,2003,108(1):1-8.
-
8Rothstein JD,Patel S,Regan MR,et al.Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.Nature,2005,433(7021):73-77.
-
9Ji HF,Shen L,Zhang HY.Beta-lactam antibiotics are multipotent agents to combat neurological diseases.Biochem Biophys Res Commun,2005,333(3):661-663.
-
10Festoff BW.The preclinical rationale for the use of insulin-like growth factor-Ⅰ in amyotrophic lateral sclerosis.Drugs Today (Barc),1998,34(1):65-77.
同被引文献47
-
1郁可,王庆松,李从阳,王俊,向阳.肌萎缩侧索硬化症患者抑郁状况调查及药物干预效果[J].脑与神经疾病杂志,2011,19(1):48-50. 被引量:5
-
2Meininger V. ALS,what new 144 years after Charcot. ArchItal Biol, 2011 , 149 : 29-37.
-
3Naganska E , Matyja E . Amyotrophic lateral sclerosis - lookingfor pathogenesis and effective therapy. Folia Neuropathol,2011, 49: 1-13.
-
4Traynor BJ,Codd MB,Corr B,et al. Amyotrophic lateralsclerosis mimic syndromes : a population - based study. ArchNeurol, 2000, 57 : 109-113.
-
5Logroscino G,Traynor BJ , Hardiman 0,et al. Incidence ofamyotrophic lateral sclerosis in Europe. J Neurol NeurosurgPsychiatry , 2010,81(4); 385-390.
-
6Duffy JR,Peach RK,Strand EA. Progressive apraxia ofspeech as a sign of motor neuron disease . Am J Speech LangPathol, 2007 , 16(3 ) : 198-208.
-
7Talbot K. Motor neuron disease : the bare essentials. PractNeurol, 2009 , 9(5 ) : 303-309.
-
8Wijesekera LC,Mathers S,Talman P , et al. Natural historyand clinical features of the flail arm and flail leg ALS vari-ants .Neurology , 2009, 72: 1087-1094.
-
9van Blitterswijk M,Landers JE. RNA processing pathways inamyotrophic lateral sclerosis. Neurogenetics, 2010, 11:275-290.
-
10Renton AE,Majonnie E,Waite A , et al. A hexanucleotide re-peat expansion in C90RF72 is the cause of chromosome 9p21 -linked AI5-FTD. Neuron,2011,72(2) : 257-268.
二级引证文献5
-
1张楠,周利晓,孙成林.利鲁唑对急性高眼压致大鼠视网膜损伤的保护作用[J].山东大学学报(医学版),2015,53(8):27-31. 被引量:2
-
2苗晓慧,耿丹,杨蓉.肌萎缩侧索硬化病人生活质量研究进展[J].护理研究(中旬版),2016,30(9):3205-3208. 被引量:3
-
3邓文友,孙艳秋.扩散峰度成像在中枢神经系统退行性疾病的应用[J].实用医学影像杂志,2016,17(4):343-345. 被引量:2
-
4涂双燕,苗晓慧,耿丹,曾玉萍,李银萍,杨蓉.肌萎缩侧索硬化患者照顾者照顾负担状况及其影响因素[J].现代临床护理,2018,17(11):7-13. 被引量:3
-
5蔡彤彤,李彦,冯淑君,黄智恒,王丽娟,张玉虎.肌萎缩侧索硬化叠加帕金森综合征临床分析[J].国际神经病学神经外科学杂志,2019,46(4):374-377. 被引量:1
-
1王倩,乐卫东.肌萎缩侧索硬化的药物治疗进展[J].中国新药与临床杂志,2008,27(1):54-59. 被引量:4
-
2冯新红,崔丽英.肌萎缩侧索硬化的药物治疗进展[J].中国神经免疫学和神经病学杂志,2010,17(3):224-227. 被引量:8
-
3陆士奇,孔小明,冀勇.尼莫地平在蛛网膜下腔出血后脑血管痉挛中的抗炎性作用[J].中国急救医学,2005,25(11):808-810. 被引量:3
-
4杜云红,穆俊林,宋景贵,马振武,顾仁骏.康复治疗对老年性痴呆患者认知功能的影响[J].郑州大学学报(医学版),2011,46(6):930-931. 被引量:6
-
5梅嵘,李求兵.康复训练对轻、中度老年性痴呆患者认知功能和ADL能力的影响[J].中国康复医学杂志,2010,25(8):797-799. 被引量:22
-
6英勇.早防早治阿尔茨海默病[J].家庭用药,2006(7):64-64.
-
7王丹.运动神经元病7例护理[J].中国乡村医药,2013,20(4):64-65.
-
8吴娟,江文宇,林卫.阿尔茨海默病的磁共振成像研究现状[J].中国医药科学,2016,6(17):27-29. 被引量:2
-
9涂怀军,周晖,吴维华.54例运动神经元病患者的临床和肌电图分析[J].实验与检验医学,2008,26(3):318-318. 被引量:2
-
10钱辉,张宝荣.阿尔茨海默病患者血脂、纤维蛋白原、同型半胱氨酸水平的变化[J].浙江医学,2010(11):1701-1702.