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肌肉特异性酪氨酸激酶抗体阳性重症肌无力的特点

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摘要 近年来,在血清乙酰胆碱受体抗体(AchRAb)阴性重症肌无力患者体内发现了一个特殊抗原———肌肉特异性酪氨酸激酶(MuSK)。MuSKAb阳性重症肌无力患者在流行病学、临床特点、诊断、胸腺病理、治疗效果及预后转归均有自己的特点。
作者 张德敏 莫雪安
机构地区 广西医科大学第一附属医院
出处 《国际神经病学神经外科学杂志》 2006年第4期337-339,共3页 Journal of International Neurology and Neurosurgery
基金 广西科学研究与技术开发计划(桂科攻03220259)
关键词 血清阴性重症肌无力 肌肉特异性酪氨酸激酶
分类号 R746.1 [医药卫生—神经病学与精神病学] R979.1 [医药卫生—药品]
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参考文献17

  • 1Maria E,Alexianu,Clifton L,et al.Advances in neuromuscular disease 2003.Journal of clinical neuromuscular disease,2004; 4(5):169-175.
  • 2Hoch W,Mc Conville J,Helms S,et al.Auto-antibodies to the tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies.Nat Med,2001,7:365 -368.
  • 3Liyanagi Y,Hoch W,Beeson D.The agrin/muscle specific kinase pathway:new targets for autoimmune and genetic disorders at the neuromuscular junction.Muscle Nerve,2002,25:4-16.
  • 4Scuderi F,Marino M,Colonna L,et al.Anti-P 110 autoantibodies identify a subtype of "seronegative" myasthenia gravis with prominent oculobulbar involement.Lab Invest,2002,82:1139-1146.
  • 5Yeh JH,Chen WH,Chiu HC,et al.Low frequency of MuSK antibody in generalized seronegative myasthenia gravis among Chinese.Neurology,2004,62:2131-2132.
  • 6Vincent A,Bowen J,Newsom-Davis J,et al.Seronegative generalized myasthenia gravis:clinical features,antibodies,and their targets.Lancet Neurol,2003,2:99-106.
  • 7Ohta K,Shigemoto K,Kubo S,et al.MuSK antibodies in AChR Ab-seropositive MG vs AChR Ab-seronegative MG.Neurology,2004,62:2132-2133.
  • 8McConville J,Farrugia ME,Beeson D,et al.Detection and characterization of MuSK antibodies in seronegative myasthenia gravis.Ann Neurol,2004,55:580-584.
  • 9Lindstrom J.Is "seronegative" MG explained by autoantibodies to MuSK? Neurology,2004,62:1920-1921.
  • 10Evoli A,Tonali PA,Padua L.Clinical correlates with anti-MuSk antibodies in generalized seronegative myasthenia gravis.Brain,2003,126(10):2304-2311.

二级参考文献32

  • 1Sanders DB, Andrews PI, Howard JF Jr, et al. Seronegative myasthenia gravis[J]. Neurology, 1997, 48(suppl 5):s40-s51.
  • 2Hoch W, McConville J, Helms S, et al. Auto-antibodies to the receptor tyrosine kinase MuSK in patients withmyasthenia gravis without acetylcholine receptor antibodies[J]. Nat Med, 2001, 7:365-368.
  • 3Valenzuela DM, Sitt TN, Distefano PS, et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury[J]. Neuron, 1995, 15:573-584.
  • 4Burden SJ. Building the vertebrate neuromuscular synapse[J]. J Neurobiol, 2002, 53:501-511.
  • 5Liyanage Y, Hoch W, Beeson D, et al. The agrin/musclespecific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction[J].Muscle Nerve, 2002, 25:4-16.
  • 6Hoch W, McConville J, Helms S, et al. Auto-antibidies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies[J]. Nat Med, 2001, 7:365-368.
  • 7Scuderi F, Marino M, Colonna L, et al. Anti-P110 autoantibidies identify a subtype of "seronegative" myastheniagravis with prominent oculobulbar involvement[J]. Lab Invest, 2002, 82:1139-1146.
  • 8Matthews I, Chen S, Smith BR, et al. Muscle-speci-fic receptor tyrosine kinase autoantibodies-a new immunoprecipitation assay[J]. Clin Chim Acta, 2004, CCA-09543:1-5.
  • 9Evoli A, Tonali PA, Padua L, et al. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis[J]. Brain, 2003, 126:2304-2311.
  • 10McConville J, Farrugia ME, Beeson D, et al. Detection and Characterization of MuSK Antibodies in seronegative myasthenia gravis[J]. Ann Neurol, 2004, 55:580-584.

共引文献4

国际神经病学神经外科学杂志
2006年 第4期

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