Wistar大鼠和昆明种小鼠血清唾液酸频率分布与参考值

The Frequency Distribution and Reference Value on Wistar Rats and KM Mice Blood Serum Sialic Acid

目的为了便于观察荷瘤实验动物血清唾液酸的变化情况，也鉴于国内文献尚无大鼠和小鼠血清正常参考值。方法采用测定血清唾液酸的定量方法。结果和结论188只大鼠血清平均唾液酸为（3．45±0．41）mmol／L，雌、雄大鼠平均唾液酸间无统计学差异（P〉0．05），大鼠总体血清唾液酸频率服从正态分布，正常参考值范围为（2．65～4．25）mmol／L。100只小鼠平均血清唾液酸为（3．04±0．30）mmol／L，雌、雄小鼠平均唾液酸间有非常显著的统计学差异（P〈0．001），小鼠总体血清唾液酸频率服从对数正态分布，其正常参考值范围为（2．44～3．64）mmol／L。

Objective To observe the change of blood serum sialic acid in experimental animal with bearing cancer, while there are no normal reference value on Wistar rats and KM mice blood serum sialic acid. Method Using quantitative method on determining blood serum sialic acid. Result and Conclusion Average blood serum sialic acid is 3.45±0.41 mmol/L in 180 Wistar rats, no statistics difference between female rats and male rats （P 〉 0.05）, Wistar rats blood serum sialic acid frequency for population obey normal distribution, the extent of normal reference value is 2.65～4.25mmol/L. Average blood serum sialic acid is 3.04±0.30 mmol/L in 1130 KM mice, there are highly significant statistics difference between female mice and male mice （P 〈 0.001）, KM mice blood serum sialic acid frequency for population obey logarithmic normal distribution, the extent of normal reference value is 2.44～3.64 mmol/L.