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Cholesterol Depletion Reduces the Internalization of β-Amyloid Peptide in SH-SY5Y Cells

Cholesterol Depletion Reduces the Internalization of β-Amyloid Peptide in SH-SY5Y Cells
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摘要 Deposition of amyloid in the brain is a critical step in the pathogenesis of Alzheimer's disease. The endocytosis of β-amyloid peptide (Aβ) is an important factor among the many factors that contribute to the genesis of amyloid deposits. Since cholesterol participates in many important physiological processes, the present work investigated the relationship between the cellular cholesterol content and the endocytosis of the exogenic Aβ, and found that reduction of the cholesterol content by methyl-β-cyclodextrin could reduce the endocytosis of AI3. The study indicates that the endocytosis of Aβ is partly mediated by cholesterol. Deposition of amyloid in the brain is a critical step in the pathogenesis of Alzheimer's disease. The endocytosis of β-amyloid peptide (Aβ) is an important factor among the many factors that contribute to the genesis of amyloid deposits. Since cholesterol participates in many important physiological processes, the present work investigated the relationship between the cellular cholesterol content and the endocytosis of the exogenic Aβ, and found that reduction of the cholesterol content by methyl-β-cyclodextrin could reduce the endocytosis of AI3. The study indicates that the endocytosis of Aβ is partly mediated by cholesterol.
出处 《Tsinghua Science and Technology》 SCIE EI CAS 2006年第4期447-451,共5页 清华大学学报(自然科学版(英文版)
基金 Supported by the National Key Basic Research and Development (973) Program of China (No. 2004CB20005)
关键词 Alzheimer's disease β-amyloid peptides internalization CHOLESTEROL methyl-β-cyclodextrin Alzheimer's disease β-amyloid peptides internalization cholesterol methyl-β-cyclodextrin
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参考文献1

  • 1Makoto Michikawa.The role of cholesterol in pathogenesis of alzheimer’s disease[J].Molecular Neurobiology.2003(1)

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