摘要
细胞表面微绒毛和细胞微丝状态与细胞运动密切相关。在人胃癌ＢＧＣ－８２３细胞系体外培养液中加用胃泌素及其受体拮抗剂，发现经胃泌素作用后的ＢＧＣ－８２３细胞微丝紊乱，细胞表面微绒毛多而密集，经Ｌ－３６５２６０作用后则微丝长而粗，排列规则，表面微绒毛少。提示，胃泌素能增强ＢＧＣ－８２３细胞系的运动，可能有促进肿瘤细胞转移的作用，这种作用可被Ｌ－３６５２６０所拮抗。
The microfilaments(MF)of human gastric Cancer cell line BGC-823 Were observed by using Coomassie Brilliant Blue R250 Staining and electron microscope.It was found that the MF of BGC-823 cell line had decreased after the treatment of gastrin and this effect could be inhibited by L-365260.These Cytoskeleton changes might be related to the biological characteristics and the metastasis and invastion of the tumor cells.
出处
《天津医科大学学报》
1996年第3期14-17,共4页
Journal of Tianjin Medical University
