盐酸二氢埃托啡用于静吸复合麻醉的临床观察

CLINICAL OBSERVATIONS ON THE DIHYDROETORPHINE HYDROCHLORIDE USED IN INHALATION-INTRAVENOUS COMBINED ANESTHESIA

将８０例静吸复合全麻病人随机分为Ａ组：盐酸二氢埃托啡（ＤＨＥ）组，Ｂ组：对照组，观察麻醉诱导插管、术中维持及术后恢复的比较。结果发现，Ａ组在静注ＤＨＥ稀释液后５ｍｉｎ、１０ｍｉｎ呼吸频率明显减慢，潮气量下降，与注药前相比有权显著性差异（Ｐ＜０．０１）。气管插管后心血管系统的应激反应，Ａ组血压无明显变化，Ｂ组血压变化较大，两组比较有显著性差异（Ｐ＜０．０５），尤其心率变化更为明显（Ｐ＜０．００１）。术后恢复期两组病人呼吸，循环无显著性差异（Ｐ＞０．０５）。采用ＤＨＥ复合麻醉对循环系统影响轻微，但对呼吸有明显抑制作用。

patients under Inhalation-Intravenous combined anesthesia were randomiy divided into DHE group (A group) and control group (B group).The process of anesthesia induction,mainteinance of anesthesia and post-operational restoration were observed.On the 5th minute and 10th minute after intravenous injection of DHE dilutent the respiratory frequency and tidal volume decreased significantly compared with the pre-anesthesia state in group A. After endotracheal intubation the stress reaction of cardiovascular system,esp. HR fluctuated apperently in group B and entirely attenuated in group A.There is significant difference between them (P<0. 05).In the post-operational restoration there is no significant difference between two groups in respiration and circulation.The observation showed that DHE combined anesthesia affeced the circulation slightly but suppressed the respiration remarkably. It is neccessary to control respiration in the anesthesia