哮喘患者血清肌酸激酶活性变化及其临床意义

The Changes of Creatin Kinase Activity in Serum from Patients with Asthma and Clinical Significance

目的探讨血清肌酸激酶(CK)活性测定在哮喘临床中的应用价值。方法测定78例哮喘患者血清肌酸激酶(sCK)、谷-草转氨酶(GOT)、乳酸脱氢酶(LDH)及羟丁酸脱氢酶(HBDH)的活性及哮喘急性期患者1s用力呼气容积占预计值的百分比(FEV1%)、动脉血气指标及15例重症哮喘患者的CK-MB活性。结果哮喘死亡组患者sCK活性显著高于哮喘重症发作组、哮喘轻、中度发作组、哮喘缓解期组及对照组(P<0.01);哮喘重症发作组sCK活性显著高于哮喘轻中度发作组、哮喘缓解期组及对照组(P<0.01)。哮喘急性期患者sCK活性与FEV1%间呈显著负相关(r=-0.589,P<0.001)。结论sCK可用于哮喘急性发作患者病情及预后的判断;哮喘重症发作患者sCK及sCK-MB活性异常增高的原因可能为呼吸肌损伤。

Objective To evaluate the clinical significance of the detection of the creatin kinase and its isoenzyme in serum from patients with asthma. Methods To calibration 78 patients with asthma the values of CK, LDH, GOT and HBDH in serum were measured, while the arterial blood gas analysis and pulmonary function were also measured in tested patients with asthma at exacerbation. Results The median concentrations of sCK in grouplll and grouplV were 285U/L and 975U/L respectively, all were significantly higher than other groups. The activity of sCK was more closely correlated with FEV1% （ r = - 0. 589, P 〈 0. 001 ） in patients with asthma at exacerbation. Conclusion The activity of sCK may be a useful marker for monitoring the degree of severity and prognosis of patients with asthma at exacerbation. The respiratory muscles injuries may be the reason of the activity of sCK increased among patients with asthma at severe attack.