81例胸部肿瘤患者肺功能与急性放射性肺损伤关系的临床观察

The clinical observation of relation between lung function and acute radiation lung injury in 81 patients with thorax tumor

目的：探讨胸部肿瘤患者放疗前的基础肺功能与放疗后发生急性放射性肺损伤的关系。方法：81例胸部肿瘤患者放疗前常规检测基础肺功能，按常规肺功能分为基础肺功能正常组（51例）和基础肺功能异常组（30例），对2组患者进行5～6周的三维适形放疗（3DCRT）或调强放疗（IMRT），比较放疗结束后2组急性放射性肺损伤的发生情况。结果：放疗结束后3个月内，81例胸部肿瘤患者中17例（21．0％）发生急性放射性肺损伤，基础肺功能正常组和基础肺功能异常组急性放射性肺损伤的发生率分别为9．8％（5／51）和40．0％（12／30），差异有统计学意义（P〈0．005）。结论：放疗前患者的基础肺功能与放疗后急性放射性肺损伤的发生具有一定关系。

Objective： To investigate the relationship between foundation lung function and acute radiation lung injury in post radiation. Methods： Normal regulations examines foundation lung function of 81 patients with thorax tumor before radiotherapy, then divided into two groups： one is the normal foundation lung function（51 cases）, another is the abnormal （30 cases）. The two groups treated with three dimensional eonformal radiotherapy （3DCRT） or intensity modulated radiotherapy （IMRT） and compared on the occurrence of acute radiation lung injury in the two groups after the radiotherapy. Results： The occurrence rate of acute radiation lung injury was 21% in the 81 cases. The occurrence rate of acute radiation lung injury was 9.8% （5/51） in normal group, and 40.0% （12/30） in the abnormal group. The difference between groups had significant （P 〈0. 005）. Conclusions：The foundation lung function of patients before radiotherapy relate with acute radiation lung injury. Abnormal foundation lung function may be dangerous factor for acute radiation lung injury.