山羊双侧下颌骨牵引成骨动物模型的建立

Establish Animal Model of Goat Mandibular Osteogenesis Distraction.

目的:建立一个可行性良好的山羊下颌骨牵引成骨模型。方法:将6只山羊的下颌骨截断,安置牵引器,延迟期4 d后以0.5 mm/次,2次/d的速度牵引10 d;随后进入固定期。分别于固定期的2、4、6、8周处死动物,进行大体标本和放射学观察。结果:牵引过程被所有山羊耐受,牵引长度达到预期效果。结论:山羊是一种良好的牵引成骨动物模型;该模型有助于DO临床的应用及研究。

Objective： To establish a goat model for mandibular distraction with reproducibility. Methods： Six goats were used in in this study. Osteotomy was performed in the mandibule and then the distractor was placed. After 4 days＇ latency, the goats were distracted with 0.5mm twice per day for 10 days followed by a consolidation period. The distracted mandibles were harvested after 2, 4, 6 and 8 weeks of consolidation. The appearance of samples and radiological changes were examined. Results： The experimental procedure was well tolerated by all animals and the expected distraction length was successfully achieved. Conclusion： The goat was a perfect model for mandibular distraction, and it could be used for further clinical investigations.