抗精神病药恶性综合征

Neuroleptic Malignant Syndrome

自从1960年首次报道抗精神病药恶性综合征(NMS)后,大量的临床案例已使人们对于NMS的发病机制、临床表现和治疗有了较深的了解。然而大多数医师对于NMS的了解依然十分有限,难以对该综合征做出及时正确的诊断。有鉴于此,文章对NMS的发病机制、临床表现、鉴别诊断和治疗作一综述。

Since the initial report of neuroleptic malignant syndrome （NMS） in 1960, lots of clinical data have been accumulated on the pathogenesis, manifestations and treatment of NMS. Nevertheless, this disorder remains obscure to most practicing physicians. Herein, we provide a clinical overview on the pathogenesis, manifestations, differential diagnosis and treatment of NMS.