期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MHC I类链相关蛋白A的表达调控与抗肿瘤免疫 被引量：5

下载PDF
导出
摘要 MHC I类链相关蛋白A(MICA)是非经典的HLA I类分子,是活化性受体NKG2D的配体,在感染、肿瘤及细胞应激情况下表达上调,其表达量及形式的变化,直接影响多种免疫效应细胞功能表现。本文就近年来对MICA的表达调控以及与抗肿瘤免疫关系方面进行综述。
作者 牛家峰 张彩
机构地区 山东省医学科学院基础医学研究所
出处 《现代免疫学》 CAS CSCD 北大核心 2006年第4期343-345,共3页 Current Immunology
基金 国家自然科学基金资助项目(30371302) 山东省自然科学基金资助项目(Y2002C24) 山东省优秀中青年科学家科研奖励基金资助项目(2005BS03015)
关键词 MICA NKG2D 肿瘤
分类号 R392.12 [医药卫生—免疫学]
  • 相关文献

参考文献18

  • 1Bahram S,Bresnahan M,Geraghty DE,et al.A second lineage of mammalian major histocompatibility complex class I genes[J].Proc Natl Acad Sci USA,1994,91(14):6259-6263.
  • 2Raulet DH.Roles of the NKG2D immunoreceptor and its ligands[J].Nat Rev Immunol,2003,3(10):781-790.
  • 3Molinero LL,Fuertes MB,Rabinovich GA,et al.Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28[J].J Leukoc Biol,2002,71(5):791-797.
  • 4Pende D,Rivera P,Marcenaro S,et al.Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes:analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity[J].Cancer Res,2002,62(21):6178-6186.
  • 5Jinushi M,Takehara T,Tatsumi T,et al.Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection[J].J Immunol,2003,171(10):5423-5429.
  • 6Zhang C,Zhang J,Sun R,et al.Opposing effect of IFNgamma and IFN-alpha on expression of NKG2 receptors:negative regulation of IFN-gamma on NK cells[J].Int Immunopharmacol,2005,5(6):1057.-1067
  • 7Molinero LL,Fuertes MB,Girart MV,et al.NF-κB regulates expression of the MHC class I-related chain A gene in activated T lymphocytes[J].J Immunol,2004,173:5583.
  • 8Jinushi M,Takehara T,Tatsumi T,et al.Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid[J].Int J Cancer,2003,104(3):354-361.
  • 9Armeanu S,Bitzer M,Lauer UM,et al.Natural killer cell mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate[J].Cancer Res,2005,65(14):6321-6329.
  • 10Gasser S,Orsulic S,Brown EJ,et al.The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor[J].Nature,2005,436(7054):1186-1190.

二级参考文献16

  • 1Huber SA, Graveline D, Newell MK, et al. Vγ1^+ T cells suppress and Vγ4^+ T cells promote susceptibility to cosackievirus B3- induced myocarditis in mice[J]. J Immunol, 2000,165:4174-4181.
  • 2Ikeda H, Old LJ, Schreiber RD. The role of IFN gamma in protection against tumor development and cancer immunoediting [J].Cytokine Growth Factor Rev, 2002, 13:95-109.
  • 3Gao Y, Yang W, Pan M, et al. Gamma delta T cells provide an early source of interferon gamma in tumor immunity [J]. J Exp Med, 2003,198:433-442.
  • 4Allison T, Garboczi DN. Structure of gamma delta T cell receptors and their recognition of non-peptide antigen [J]. Mol Immunol, 2001,38:1051-1061.
  • 5Hayday AC. Gamma delta cells: a right time and a right place for a conserved third way of protection[J]. Annu Rev Immunol, 2000,18:975-1026.
  • 6Mak TW, Ferrick DA. The gamma delta T-cell bridge: linking innate and acquired immunity[J]. Nat Med, 1998, 4:764-765.
  • 7Groh VR, Rhinehart H, Secrist S, et al. Recognition of stress-induced MHC molecules by intestinal epithelial gamma delta T cells[J]. Science, 1998, 279:1737-1740.
  • 8Dighe AS, Richards E, Old LJ, et al. Enhanced in vivo growth and resistant to rejection of tumor cells expressing dominant negative IFN gamma receptor[J]. Immunity, 1994, 1:447-456.
  • 9Glimcher LH, Murphy KM. Lineage commitment in the immune system: the T helper lymphocyte grows up[J]. Genes Dev, 2000,14:1693-1711.
  • 10Ferrick DA, Schrenzel MD, Mulvania T, et al. Differential production of interferon gamma and interleukin-4 in response to Th1 and Th2 stimulating pathogens by gamma delta T cells in vivo[J].Nature, 1995, 373:255-257.

共引文献3

同被引文献73

  • 1马庆,陈亮,郭晓俊,谢军华,陆琼,张景怡,冯明亮.中国南方汉族人群MICA-TM基因座等位基因分布[J].临床输血与检验,2004,6(4):241-243. 被引量：4
  • 2陈永玲,王昌富.MHC-I链相关基因A的生物学特性及与疾病的关联[J].国际检验医学杂志,2006,27(5):451-453. 被引量：1
  • 3牛家峰,张彩,张建华,许晓群,张维东,王郡甫,高春义.IFN-α对宫颈癌细胞MHC-I类链相关蛋白A表达的上调作用[J].细胞与分子免疫学杂志,2006,22(5):557-559. 被引量：3
  • 4丁军颖,王润田.人MICA基因多态性和表达特性与肿瘤的关系[J].现代免疫学,2007,27(2):165-168. 被引量：10
  • 5MERCHANT M S, MELCHIONDA F, SINHA M, et al. Immune reconstitution prevents metastatic recurrence of routine osteosarcoma[J]. Cancer Immunol Immunother, 2007, 56 (7) : 1037 - 1046.
  • 6RAULET D H. Roles of the NKG2D immunoreceptor and its ligands[J]. Nat Rev Immunol, 2003, 39(10): 781- 790.
  • 7SALIH H R, RAMMENSEE H G, STEINLE A. Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding[J]. J Immunol, 2002, 169(8): 4098-4102.
  • 8GROH V, WU J, YEE C, et al. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation[J]. Nature, 2002, 419(6908): 734-738.
  • 9WATSON N F, SPENDLOVE I, MADJD Z, et al. Expression of the stress-related MHC class I chain-related protein is an indicator of good prognosis in colorectal cancer patients[J]. Int J Cancer, 2006, 118(6) : 1445 - 1452.
  • 10MADJD Z, SPENDLOVE I, MOSS R, et al. Upregulation of MICA on high-grade invasive operable breast carcinoma[J]. Cancer Immun, 2007, 7: 17.

引证文献5

二级引证文献16

现代免疫学
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部