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CD4^+ CD28^- T淋巴细胞与自身免疫性疾病 被引量:5

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摘要 CD4+CD28-T细胞是一个具有特殊生物学效应的细胞亚群,高频出现于某些自身免疫性疾病中,具有细胞毒样的侵蚀特性、T细胞活化的不平衡性及抗凋亡特征,与疾病的发生、发展及转归密切相关。
出处 《现代免疫学》 CAS CSCD 北大核心 2006年第4期346-349,共4页 Current Immunology
基金 国家自然科学基金资助项目(30471609) 江苏省高校实验室开放课题基金资助项目(KJS02015)
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参考文献14

  • 1Markovic-Plese S,Cortese I,Wandinger KP,et al.CD4+ CD28- costimulation independent T cell in multiple sclerosis[J].J Clin Invest,2001,108(8):1185-1194.
  • 2Komocsi A,Lamprech P,Csernok E,et al.Peripheral blood and granuloma CD4^+ CD28- T cells are a major source of interferon-γ and tumor necrosis factor-α in Wegener's granulomatosis[J].Am J Pathol,2002,160(5):1717-1724.
  • 3Veena T,Nee T,Marshall B,et al.Requirement for CD28 may not be absolute for collagen-induced arthritis:study with HLA-DQ8 transgenic mice[J].J Immunol,2005,174:1118-1125.
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二级参考文献1

  • 1张季平.临床内科学[M].天津:天津科学技术出版社,2000.2809.

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