重视我国角膜病的基础研究

More attention should be paid to the basic research on corneal diseases

角膜病是我国主要的致盲眼病之一,其临床诊疗水平的提高有赖于基础与应用基础研究的深度与广度。我国在角膜病的基础与应用基础研究的某些领域已处于国际先进水平。但是总体来说,目前我国角膜病的基础研究与发达国家仍存在较大差距,具体体现在缺乏系统性研究、研究经费有限、从事研究人员的素质与数量均不够等方面。今后我国的角膜病基础研究应主要集中在感染性角膜病的发病机制、角膜营养不良的致病基因、角膜的组织工程、干眼的发病机制、严重眼表化学伤的组织重建、眼表新生血管的发病机制与预防、移植排斥反应的治疗药物开发等方面。争取研究经费、培养高素质人才及加强国内外和不同学科间的合作是提高我国角膜病基础研究的重要工作。

Corneal disease is the second leading cause of blindness in China. Improvement of the diagnosis and treatment of corneal disease depends on the deepening and widening of the basic research in this area. In some fields, the research conducted in our country has reached the top level in the world. However, in general, obvious disparities exist between China and the developed countries in terms of lack of systematic research, limited financial support, the insufficiency of the quality and quantity of researchers and so on. Based upon the current situations of China, the future basic research on corneal diseases should focus on the mechanism of infectious corneal diseases, gene mutation of corneal dystrophy, corneal tissue engineering, the pathogenesis of dry eye, the reconstruction after severe chemical burns of ocular surface, the pathogenesis of ocular surface neovascularization, the prophylaxis and therapy of corneal graft rejection, etc. Other important measures to improve the basic research of corneal diseases in our country would include applying for more research funds, training high quality researchers, and strengthening the cooperation with different disciplines and with other countries. （Chin J Opbthalmol, 2006,42：673-675）