摘要
With the many changes that have taken place in people＇s diet and lifestyle, colorectal cancer （CRC） has become a global concern. There were approximately 950000 new cases diagnosed and 500000 deaths recorded worldwide in 2000. It is the second most common type of cancer in the Western world, and it is the third most common type of digestive tumor in China. It is reported that the morbidity of CRC is 4.08/100000 for men and 3.30/100000 for women in China. Despite the rate of improvements in surgery, radiotherapy and chemotherapy, the overall five-year survival is around 50%. Therefore, novel treatment need to be developed in order to add to the therapeutic armamentarium. RNA interference （RNAi） is a sequence-specific posttranscriptional gene silencing mechanism, which is triggered by double-stranded RNA （dsRNA） and causes degradation of mRNA homologous in sequence to the dsRNA.This new approach has been successfully adopted to inhibit virus replication and tumorigenicity. Recent reports have described DNA vector-based strategies for delivery of small interfering RNA （siRNA） into mammalian cells, further expanding the utility of RNAi. With the development of the RNAi technology and deeper understanding of this field, a promising new modality of treatment appeared, which can be used in combination with the existing therapies .We reviewed the proceedings on the actualities and advancement of RNAi technology for colorectal cancer therapeutics.
与发生在人的食谱和生活方式的许多变化，渲染表面的癌症(CRC ) 成为了一颗全球担心。有约 950000 个新盒子和在 2000 全球记录的 500000 死亡，诊断。它是在西方的世界上的癌症的第二种很普通的类型，并且它是在中国的消化肿瘤的第三种很普通的类型。CRC 的病态为在中国的女人是为男人和 3.30/100000 的 4.08/100000，这被报导。尽管有在外科，放射疗法和化疗的改进的率，全面五年的幸存在 50% 附近。因此，要发展以便增加治疗学的一套设备的新奇治疗需要。RNA 干扰(RNAi ) 是顺序特定的 post-transcriptional 基因 silencing 机制，它被双 stranded RNA (dsRNA ) 和在顺序相应的 mRNA 的原因降级触发到 dsRNA.This 新途径成功地被采用了禁止病毒复制和 tumorigenicity。最近的报告描述了 DNA 为进哺乳动物的房间的小介入 RNA (siRNA ) 的交货的基于向量的策略，进一步扩展 RNAi 的用途。与 RNAi 技术的发展和这块地的更深的理解，治疗的一种有希望的新形式出现了，它能与存在治疗在联合被使用。我们为颜色在 RNAi 技术的事实和前进上考察了论文录表面的癌症治疗学。
