摘要
瞄准:评估为肝细胞癌(HCC ) 的早察觉屏蔽的 ultrasonographic 的有效性。方法:为长期的肝疾病有 ultrasonography (美国) 的 14968 个病人的数据从 1995 年 6 月被收集进一个数据库节目到 2005 年 6 月。为 HCC 的风险因素也被学习。重复了美国的 6089 个病人的一个总数被注册, 264 个病人在后续期间与 HCC 被诊断(平均数, 39 瞬间) 。结果:小 HCC 的察觉率(【= 在直径的 3 厘米) 是 67.7% 。在 6 瞬间的间隔屏蔽检测的肿瘤尺寸在更长的间隔是比那显著地小的。仅仅, 29.3% HCC 病人有一座提高的浆液高山哈在 400 ng/mL 上面的 fetoprotein (法新社) 水平。HCC 开发的风险比在有长期的肝炎(4.2%) 的病人在有肝肝硬化(10.9%) 和丙肝(9.0%) 的病人在后续期间是更高的,肝炎 B (4.9%) 和 non-B, non-C 肝炎(NBNC, 3.9%) 。结论:在 6 瞬间的间隔屏蔽的美国对超过 40 岁的高风险的病人有益, HCC 的早察觉延长幸存。
AIM: To evaluate the effectiveness of ultrasonographic screening for early detection of hepatocellular carcinoma (HCC).
METHODS: The data of 14 968 patients who had ultrasonography (US) for chronic liver diseases were collected into a database program from June 1995 to June 2005. The risk factors for HCC were also studied. A total of 6089 patients who had repeated US were enrolled, 264 patients were diagnosed with HCC during follow-up (mean, 39 mo).
RESULTS: The detection rate of small HCC (≤ 3 cm in diameter) was 67.7%. The tumor size detected by screening at the intervals of 6 mo was significantly smaller than that at longer intervals. Only 29.3% of HCC patients had an elevated serum alpha fetoprotein (AFP) level above 400 ng/mL. The risk of HCC development during follow-up was higher in patients with liver cirrhosis (10.9%) and hepatitis C (9.0%) than in patients with chronic hepatitis (4.2%), hepatitis B (4.9%) and non-B, non-C hepatitis (NBNC, 3.9%). CONCLUSION: US screening at a interval of 6 mo is beneficial to high-risk patients over 40 years old and the early detection of HCC prolongs survival.