葛根素固体自微乳的研制

Preparation of Puerarin Solid Self-microemulsion

目的:研制葛根素固体自微乳制剂。方法:利用伪三元相图优化自微乳处方,并进行自微乳效率的研究,主要包括黏度、电导率、折光、zeta、粒径、稳定性,溶出度。结果:优化的葛根素固体自微乳处方为:葛根素-吐温80-甘油-油酸乙酯-水-微粉硅胶-甘露醇的重量比为1.7∶16.6∶16.6∶1.3∶4.0∶39.9∶19.9,分散后平均粒径为30 nm,10 m in时的溶出度为94.29%。结论:所制葛根素固体自微乳稳定性好,溶出迅速。

Objective： To prepare puerarin solid self-microemulsifying drug delivery system （SMEDDS）. Methods： Pseudo-ternary phase diagram was used to select the formula of microemulsion. The self-microemulsification efficiency was assessed, such as viscosity, conductance, refraction, zeta potential, size ditribution, dissolution were investigated. Puerarin were determined by UV to calculate the cumulative release at different time. Results： The optimum formulation of puerarin solid self-microemulsifying drug delivery system the consisted of puerarin-Tween 800glycerinum-ethyl oleate-water-Gum Acacia-manicol at weight ratio of 1.7： 16.6： 16.6：16.6 ： 1.3： 4. 0： 39.9： 19. 9 ; Average particle diameter was 30nm; The dissolution was 94. 29% at 10 rain. Conclusion： Stability of puerarin solid self-microemulsion drug delvery system is good, potent in improving the dissolution of puerarin.