羧甲基纤维素钠在卵巢癌介入治疗中的应用

The Application of Sodium Carboxymethycellulose in the Interventional Treatment of Ovarian Carcinoma

目的观察羧甲基纤维素钠(CM C)作为抗癌药物载体用于卵巢癌介入治疗的可行性。方法三组各6例晚期卵巢癌患者,分别给予碘油-阿霉素(ADM)、单纯ADM、CM C-ADM行髂内动脉注射,并动态观察各组ADM的血药浓度。结果单纯ADM注射组的药物峰值较高(1.95μg/m l),下降迅速;碘油-ADM和CM C-ADM注射组的药物峰值较低(0.75μg/m l和0.92μg/m l),但下降缓慢,与单纯ADM注射组的差异有统计学意义(P<0.05)。结论CM C作为抗癌药物载体,在卵巢癌介入治疗中具有较好的缓释性和安全性。

[Objective] To study the feasibility of sodium Carboxymety- lcellulose （CMC） as an anticancer drug carrier in the transcatheter intra-arterial chemotherapy for ovarian carcinoma. [Methods] To detect the plasma concentration of adriamycin （ADM） dynamically in patients with advanced stage ovarian carcinoma after infusing Lip-ADM （n= 6）, ADM-alone （n=6） and CMC-ADM （n= 6） respectively via internal iliac artery and then compare the results. [Results] The peak level of ADM in ADM-alone infusion group was high （1.95μg/ ml） and decreased rapidly. The peak levels of ADM in Lip-ADM and CMC-ADM groups were relatively low （0. 75 μg/ml and 0. 92μg/ml） and decreased slowly. Compared with ADM-alone infusion group, there were significant difference （P〈0.05）. [Conclusion] CMC as an anticancer drug carrier had better delayed release capability and safety in the interventional treatment of ovarian carcinoma.