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经皮冠状动脉自体骨髓间充质干细胞移植治疗缺血性心力衰竭26例 被引量:3

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摘要 取26例心功能Ⅱ~Ⅳ级、的缺血性心力衰竭患者自体骨髓50ml,制成骨髓间充质干细胞(BMMSCs)悬液。将悬液经冠状动脉注入病变区及其周围。结果移植12周后,心绞痛发作次数明显减少,心功能提高1~2级,生活质量明显改善;左心室收缩末直径缩短,心脏收缩速度、射血分数及心排血量提高;血浆脑钠素(BNP)水平较移植前显著下降;患者无死亡、低心排综合征、新的心肌损害及严重的心律失常。提示经皮冠状动脉内途径自体BMMSCs移植治疗缺血性心力衰竭安全、有效、可行。
出处 《山东医药》 CAS 北大核心 2006年第23期58-59,共2页 Shandong Medical Journal
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