抑制性受体对淋巴细胞活化的调节作用

The Regulation of Lymphocyte Ativation by Inhibitory Receptors

淋巴细胞在接受正向活化信号的同时也接受各种抑制性信号的调节,以维持机体正常的稳态,避免免疫应答过度对机体的病理损坏。调节淋巴细胞活化的抑制性受体主要包括3类:识别MHC分子的抑制性受体、抑制性Fc受体及与B7家族成员结合的抑制性受体,系统地了解其种类、配体、作用机制、与疾病的关系等将为人们进一步深入了解免疫应答的调控机制提供参考。

The function of leukocytes is regulated by the integration of positive and negative signals received through cell surface receptors. Inhibitory receptors can limit, terminate and/ or attenuate immune responses, and maintain the homeostasis. There are three main identified groups of inhibitory receptors, including inhibitory MHC-recognized receptors, inhibitory Fc receptors and inhibitory receptors binding to B7 family members. Studies are beginning to reveal the categories, ligands, mechanisms and functions in diseases of these receptors. A better understanding of these inhibitory mechanisms will provide a foundation for therapeutically modulating these processes in antiviral immunity, anti-tumor responses and autoimmune diseases.