蓖麻毒素拮抗剂及疫苗研究概况

Current Status of Antagonist and Vaccine for Toxic Ricin

自“911”以后,蓖麻毒素已被列为最有可能被用作恐怖袭击的生物战剂,作为目前最具危险性和威胁性的生物恐怖病原必须引起我们的高度警觉。研究其拮抗剂及疫苗具有重要的现实意义。从中和性抗体、抗RTA适配体、Ricin的小分子拮抗肽、抗独特型疫苗、重组疫苗、超级疫苗、微球疫苗等多方面对国内外的研究现状进行阐述非常必要。

After“9.11”, ricin is once known as the most toxic compound and is now listed as a most fetal agent of warfare or terrorist. We must pay high attention to this dangerous agent. Therefore, the development of antagonist and vaccine to inhibit toxin would have practical importance. This review focuses on the current research involved in neutralizing antibodies, aptamers of anti-RTA, small molecule inhibitor, anti-idiotype vaccine, recombination DNA vaccine, super vaccine and polymeric micro spheres vaccine which car interact with the agent, in order to defend this fatal toxin.