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CD38分子的表达及临床应用前景 被引量：4

The Expression and Clinical Application Prospect of CD38
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摘要 CD38分子是单链II型跨膜糖蛋白,广泛表达于造血细胞及非造血细胞系,具有许多复杂而又独特的生物学特性及功能。近年来临床研究发现CD38分子是慢性B淋巴细胞白血病的预测因子,自身免疫反应性糖尿病的诊断指标,并可用于艾滋病及巨细胞病毒的检测及系统性红斑狼疮的病情监测。 CD38 is a type Ⅱ transmembrane glycoprotein with complicated and distinct enzyme activity, and is generally expressed hematopoietic cell and nonhematopoietic cells. CD38 is a prognostic molecule in B-cell chronic lymphocytic leukemia cells, the diagnostic factor of autoimmune response diabetes . In recent years CD38 is applied to detect AIDS and cytomegalovirus infections, and monitor the pathogenetic condition of SLE.
作者 郑丽平 张伟京（审校）
机构地区 北京市中西医结合医院 军事医学科学院附属
出处 《国际免疫学杂志》 CAS 2006年第4期245-248,共4页 International Journal of Immunology
关键词 CD38 表达 临床应用 CD38 Expression Clinical application
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献18

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二级参考文献8

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  • 3[2]Spronk PE, Van-Dcr-Gun BT, Limbury PC, et al. B cell activation in clinically quiescent systemic lupus erythematosus (SLE) is related to immunoglobulin levels, but not to levels of anti-dsDNA, nor to concurrent T cell activation. Clin Exp Immunol, 1993,93(1) :39
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共引文献23

同被引文献41

  • 1侯娜莉,李宁丽,张冬青.趋化性细胞因子及其受体与类风湿性关节炎[J].现代免疫学,2004,24(5):432-434. 被引量：6
  • 2吴引伟,赵伟,夏海鸣.慢性乙型肝炎患者外周血B淋巴细胞及其活化状况研究[J].山东医药,2005,45(31):1-2. 被引量：4
  • 3邱莲女,朱永泽,周永列,骆思媛,李宏波.慢性乙型肝炎患者外周血淋巴细胞CD8^+CD38^+的检测意义[J].中国免疫学杂志,2006,22(8):768-770. 被引量：5
  • 4陆忠华,裴浩,居朝霞,丁虹.乙型病毒性肝炎肝组织不同炎症分级与CD8^+淋巴细胞数量的关系[J].国际免疫学杂志,2006,29(5):339-340. 被引量：4
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  • 6Ausiello CM, La Sala A, Funaro A, et al. Seccretion of INF-γ, IL-6, granulocyte-macrophage colony-stimulating factor and IL-10 cytoklnes after activation of human purified T lymphocytes upon CD38 ligation [J]. Cell Immunol, 1996, 173(2):192-197.
  • 7SUN L, Jameel Q, Svetlana D, et al. Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption[ J]. FASEB, 2003, 17(3) : 369 -375.
  • 8Frances J, Drummond. John. mackrill, Kathleen O, et al. CD38 is associated with premenopausal and posymenopausal bone mineral density and postmenopausal bone loss [ J ]. J Bone Miner metab, 2006, 24 (1) : 28 -35.
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  • 10WEDEMEYER H,HE X S,NASCIMBENI M,et al.Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection[J].J Immunol,2002,169(6):3447-3458.

引证文献4

二级引证文献6

国际免疫学杂志
2006年 第4期

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