摘要
目的观察国产吉西他滨(GEM)联合顺铂(DDP)治疗复发性乳腺癌的疗效及毒副作用。方法采用GEM与DDP联合治疗复发性乳腺癌患者36例。化疗剂量:GEM1000mgm2d1、8静滴;DDP25mgm2d1~3静滴;21天为一个周期,至少治疗两周期。结果CR3例,PR17例,SD10例,PD6例,总有效率(CR+PR)55.55%。毒副作用主要为骨髓抑制,恶心、呕吐等。白细胞及血小板减少的发生率分别为61.11%和58.33%,恶心、呕吐发生率为61.11%。结论GEM联合DDP治疗复发性乳腺癌疗效好,毒副作用可耐受,有较好的临床应用价值。
Objective To evaluate the efficacy and toxicity of combined chemotherapy with gemcitabine (GEM) plus cisplatin (DDP) in the treatment of recurrent breast cancer. Methods Thirty- six patients with recurrent breast cancer were enrolled for this study. GEM were administered 1 000 mg/m^2 on day 1,8 ; DDP 25 mg/m^2 on day 1 ~ 3, which was recycled every 3 weeks and with at least 2 cycles. Results Among 36 patients, 3 patients achieved completed response, 17 patients achieved partial response, 10 patients achieved stable disease and 6 patients achieved progressive disease. The overall response rate is 55.55 %. The main tox- icities were myelosuppression, nausea and vomiting. Leukopenia accounted for 61.11%, thrombocytopenia accounted for 58.33 %, nausea and vomiting accounted for 61.11%. Conclusion The schedule of gemcitabine plus cisplatin in the treatment for 36 cases of recurrent breast cancer has good clinical efficacy and tolerability, the regimen could be quite clinically valuable.
出处
《实用肿瘤学杂志》
CAS
2006年第4期278-279,共2页
Practical Oncology Journal
关键词
吉西他滨
顺铂
联合化疗
复发性乳腺癌
Gemcitabine
Cisplatin
Combined chemotherapy
Recurrent breast cancer