1Pisani P,Parkin DM,Bray F,et al.Estimates of the worldwide mortality from 25 cancers in 1990[J].Int J Cancer,1999;83(1):18~29
2Asamoto M,Toriyama-Baba H,Ohnishi T,et al.Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis[J].Jpn J Cancer Res,2002;93(7):744~751
3Liston BW,Gupta A,Nines R,et al.Incidence and effects of Ha-ras codon 12 GA transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus[J].Mol carcinog,2001;32(1):1~8
4Lord RV,O'Grady R,Sheehan C,et al.K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction[J].J Gastroenterol Hepatol,2000;15(7):730~736
6Sarbia M,Arjumand J,Wolter M,et al.Frequent c-myc amplification in high-grade dysplasia and adenocarcinoma in Barrett esophagus[J].Am J Clin Pathol,2001;115(6):835~840
7Tselepis C,Morris CD,Wakelin D,et al.Upregulation of the oncogene c-myc in Barrett's adenocarcinoma:induction of c-myc by acidified bile acid in vitro[J].Gut,2003;52(2):174~180
8Sarbia M,Loberg C,Wolter M,et al.Expression of bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus[J].Am J Pathol,1999;155(4):1027~1032
9Saito H,Tsujitani S,Oka S,et al.The expression of murine double minute 2 is a favorable prognostic marker in esophageal squamous cell carcinoma without p53 protein accumulation[J].Ann Surg Oncol,2002;9(5):450~456
10Ikeguchi M,Ueda T,Fukuda K,et al.Expression of the murine double minute gene 2 oncoprotein in esophageal squamous cell carcinoma as a novel marker for lack of response to chemoradiotreatment[J].Am J Clin Oncol,2002;25(5):454~459
5[1]Steck PA,Pershouse MA,Jasser SA,et al.ldentification of a candidate tumor Suppressor gene,MMACL,at chromosome 10q23.3 that in mutated in maltiple advanced Can-cers.Nat Genet,1997,15(1):356-342.
6[2]Li DM,Sun H.TEP1,encoded by a candidate tumor suppressor locus,is a novel protein tyrosine phosphatase regalated by transforming growth factor B.Cancer Res,1997,57(11):2124-2134.
7[3]Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyrosine phosphatase gene mutated in human,breast,and prostate cancer.Science,1997,275(9):1943-1960.
8[4]Cantley LC,Neel BG.NEW insights into tumor suppression.PTEN suppless tumor formatim by restrainign the phospho-in -ositide- 3-kinase/AKT pathway.Pro Natl Sci USA,1999,96(12):4240-4248.
9[5]Bresalier RS,Ho SB,schoeppner,et al.Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis.Gastroentrology,1996,110(9):1354-1367.
10[6]Eng C,Peacoke M.PTEN and inherited hamartoma-canver syndroms.Nat Genet,1998,19(1):223-230.