c-myc在肝细胞肝癌中的表达及其临床意义

EXPRESSION AND CLINICAL IMPLICATION OF C-MYC IN HEPATOCELLULAR CARCINOMAS

目的检测肝细胞肝癌中c-myc蛋白表达情况,研究其与肝癌临床特征的关系,探讨c-myc在肝细胞癌(HCC)发生、发展及转移中的作用。方法采用免疫组织化学技术检测59例肝癌组织及癌旁非癌组织中c-myc蛋白的表达。结果59例肝癌组织中35例c-myc呈阳性表达,阳性率为59.3%。肿瘤组织表达阳性率高于癌旁非癌组织(P<0.05)。c-myc的表达与肝癌的发病年龄,性别,肿瘤大小,分化程度无关(P均>0.05),而与肝癌的转移有关(P<0.05)。应用Kaplan-Meier法制作累积生存曲线并经Log-Rank检验结果显示,c-myc表达阳性与阴性组患者术后累积生存率有显著性差异(P=0.0039)。结论c-myc在肝细胞肝癌中的表达能促进肝癌的发生发展,HCC患者c-myc表达阳性者预后不良,应密切随访。

Objective To investigate the expression of c-myc and its relationship with the clinical feature of hepatocellular carcinoma（HCC）. Methods In 59 specimens of HCC tissues and noncancerous adjacent liver tissues, the expression of c-myc was detected with immunhischemistry. Results Of the 35（59.3% ）cases of HCC expression c-myc in 59 cases of HCC, the expression rate of c-myc was higher than that of the adjacent noncancerous liver and the normal liver groups（P〈0. 05）. The expression of c-myc in HCC had no association with patient＇s age and sex, the tumor size and differentiated level of HCC （P〉0.05）, but with the metastasis of HCC （P〈0.05）. By Ka- plan-Meier Log-Rank estimation, it was found that the positive expression of c-myc was associated with poorer survival compared with the negative expression （P = 0. 0039）. Conclusion c-myc probably promotes the metastasis of HCC, and is demonstrated as the prognostic factor for patients undergoing hepatic resection.