女性患者淋病奈瑟球菌的耐药性分析

Antibiotic resistance of Neisseria gonorrhoeae isolates from female patients

目的了解女性淋病患者中分离的淋病奈瑟球菌对抗菌药物的耐药性。方法用纸片扩散法检测淋病奈瑟球菌对7种抗菌药物的敏感性,用头孢硝噻吩检测产青霉素酶淋病奈瑟球菌(PPNG)。结果95株淋病奈瑟球菌中PPNG检出率40．0%(38/95),95株淋病奈瑟球菌对大观霉素敏感率100%,对青霉素、四环素、喹诺酮类药物的敏感率仅0%～2．6%,对头孢呋辛、头孢曲松、头孢噻肟的敏感率均高于90%。结论大观毒素和头孢菌素类药物可作为治疗女性淋病奈瑟球菌感染的首选药物。

Objective To investigate antibiotic resistance of Neisseria gonorrhoeae strains isolated from female patients. Methods： Antimicrobial susceptibility of N. gonorrhoeae to 7 antibiotics was tested by disk diffusion method and penicillinaseproducing N. gonorrhea（PPNG） was confirmed by nitrocefin disk. Results： Of the 95 strains collected, 38 （40 %） were found to be PPNG. No resistance to spectinomycin was identified. The susceptibility rate of these isolates to penicillin, tetracycline, and ciprofloxacin were much lower, only from 0% to 2.6% More than 90% of the isolates were susceptible to cefuroxime, ceftriaxone, and ceftizoxime. Conclusions： Our study suggests that spectinomycin, cefuroxime, ceftriaxone, ceftizoxime are the first choice for treatment of gonorrhea in female patients.