摘要
目的探讨卵巢纤维卵泡膜细胞瘤合并血清CA125升高病例的临床特征和血清CA125升高的原因。方法回顾性分析8例卵巢纤维卵泡膜细胞瘤合并血清CA125升高患者的临床和病理资料,用免疫组化EnvisinTM法检测CA125和VEGF蛋白在肿瘤以及大网膜组织中的表达情况。结果8例卵巢纤维卵泡膜细胞瘤临床特征为单侧附件实质性包块,质地硬,与周围组织无黏连;影像学检查显示肿块内部血流缺乏或血流稀疏,无腹腔内转移病灶征象。其血清CA125中位值158IU/ml。免疫组化提示肿瘤和大网膜的CA125蛋白表达均为阴性,而VEGF均为强阳性。结论卵巢纤维卵泡膜细胞瘤合并血清CA125升高者术前经常误诊为卵巢癌。肿瘤细胞自身不分泌CA125,其血清CA125升高的机制有待进一步研究。
Objective To explore the clinical features of ovarian fibrothecoma with elevated serum CA125 levels and the reasons of increased serum CA125. Methods The clinical and pathological data of 8 cases of ovarian fibrothecoma with elevated serum CA125 levels were retrospectively analyzed. Expression of CA125 and vascular endothelial growth factor （VEGF） were detected by using immunohistochemistry （EnvisionTM Method ）. Results The tumors were unilateral mobile solid adnexal masses without adhesion to surrounding tissues. Imaging examination showed the absence or sparsity of the internal blood vessels in the tumors and no evidence of metastasis. Serum CA125 concentration was 158IU/ml （M, median）. Immunohistochemical staining for CA125 expression was negative in tumors and in omentum, while expression of VEGF showed strong positive in tumors. Conclusions The tumor cells do not secrete CA125 . The mechanism of elevation of serum CA125 levle in ovarian fibrothecoma needs to be further studied.
出处
《浙江预防医学》
2006年第9期6-7,10,共3页
Zhejiang Journal of Preventive Medicine
