期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

3-甲硫基苯胺的制备 被引量：2

Preparation of 3-(Methylthio)benzenamine
下载PDF
导出
摘要 以硝基苯为起始原料,经氯磺化反应、还原反应(KI/H3PO3)、还原反应(Na2S)、甲基化反应、还原反应(Fe/HCl),制得3-甲硫基苯胺(1)。优化了反应条件,简化了操作,总收率50.3%,纯度99.1%(HPLC)。 3-（Methyhhio）benzenamine （1） was obtained from nitrobenzene through 5-step reactions including chlorosulfonation, reduction with KI/H3PO3, reduction with Na2S, methylation and reduction with Fe/HCl. The overall yield was 50.3%, and purity 99.1%（HPLC）. The procedure developed had several advantages of facile reaction conditions, convenient operation and cheap reagents.
作者 任戎 张翌 刘登科 王松青
机构地区 天津大学药物科学与技术学院 天津药物研究院
出处 《精细化工中间体》 CAS 2006年第4期16-17,20,共3页 Fine Chemical Intermediates
基金 天津市科委基础科学重点资助项目(033801911)
关键词 3-甲硫基苯胺 还原反应 制备 双(3-硝基苯基)二硫化物 3- （methylthio） benzenamine reduction preparation bis （3-nitrophenyl） disulfide
分类号 TQ246.342 [化学工程—有机化工]
  • 相关文献

参考文献8

  • 1Kiyama R,Kanda Y,Tada Y,et al.Preparation of heterocyclic compds.as integrase inhibiting antiviral agents[P].WO:03 016 275,2003-02-27.
  • 2Reddy E P,Reddy M V R,Cosenza S C,et al.Protection of tissues and cells from cytotoxic effects of ionizing radiation by ABL inhibitors[P].WO:2 005 044 181,2005-05-19.
  • 3Moran E J,Jacobsen J R,Leadbetter M R,et al.Preparation of aryl aniline β-2 adrenergic receptor agonists[P].US:2 003 229 058,2003-12-11.
  • 4Ochiai H,Ishida A,Ohtani T,et al.New orally active PDE4 inhibitors with therapeutic potential[J].Bioorganic & Medicinal Chemistry,2004,12 (15):4 089-4 100.
  • 5Berrut S,Dimarcq J L,Guenneugues M.New norcantharidin derivatives e.g.used for treating cancer,neurodegenerative disease,restenosis,diabetes,asthmand,bacterial and fungal infections[P].FR:2860793,2005-04-15.
  • 6Medon M,Gondorwicz F,Mazurek P.M-methylthioaniline[P].POL:56 970,1969-03-10.
  • 7Joseph L,Joseph H M.Production of alkyl m-aminophenyl sulfides[P].US:3 166592,1965-01-19.
  • 8Joseph L,Joseph H M.Production of aromatic disulfides[P].US:2986581,1961-05-30.

同被引文献13

  • 1Qi Xun SHI Rong Wen LU Zhu Xia ZHANG De Feng ZHAO.Reduction of Sulphur-containing Aromatic Nitro Compounds with Hydrazine Hydrate over Iron(III) Oxide-MgO Catalyst[J].Chinese Chemical Letters,2006,17(4):441-443. 被引量：2
  • 2Qi Xun SHI Rong Wen LU Zhu Xia ZHANG De Feng ZHAO.Preparation of Sulphur-containing Aromatic Amines by Reduction of the Corresponding Aromatic Nitro Compounds with Hydrazine Hydrate over Iron Oxide Hydroxide Catalyst[J].Chinese Chemical Letters,2006,17(8):1045-1047. 被引量：1
  • 3VANHAESEBROECK B,I.F.F.VERS S J ,AHMADI K, et al. Synthesis and function of phosphorylated inositol lipids[ J]. Annu Rev Biochem ,2001,70:535 - 602.
  • 4SOLIT D B,BASSO A D,OLSHEN A B,et al. Inhi- bition of heat shock protein 90 function down-regu- lates Akt kinase and sensitizes tumors to taxol [ J ]. Cancer Res ,2003 ,63 (9) :2139 - 2144.
  • 5GARCIA E C, SELLERS W R. Drug discovery ap- proaches targeting the PI3K/Akt pathway in cancer [ J ]. Oncogene ,2008,27 (41) :5511 - 5526.
  • 6BAJJALIEH W,BANNEN L C,BROWN S D,et al. Phosphatidylinositol-3-kinase inhibitors and methods of their use : WO, 2007044729 ( A2 ) [ P ]. 2007 - 04 - 19.
  • 7ROMER D R. Synthesis of 2,3-dichloroquinoxalines via vilsmeier reagent chlorination [ J ]. J Heterocycl Chem,2009,46(2) :317 -319.
  • 8OKAFOR C O. Studies in the heterocyclic series XVII. A new type of tdazaphenothiazine heterocycle [ J ]. J Heterocycl Chem, 1980,17 ( 1 ) : 149 - 153.
  • 9SAMANTA S, SRIKANTH K, BANERJEE S, et al. 5-N-Substituted-2-( substituted benzenesulphonyl ) glutamines as antitumor agents. Part II: synthesis, biological activity and QSAR study [ J ]. Bioorg Med Chem,2004,12(6) :1413 - 1423.
  • 10PRICE C C, REITSEMA R H. Some sulfonamide de- rivatives of 2-aminobenzimidazole [ J ]. J Org Chem, 1947,12 (2) :269 - 274.

引证文献2

二级引证文献1

精细化工中间体
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部