阿托伐他汀改善冠心病合并肾功能不全患者肾功能

Atorvastatin improved the renal function in patients with coronary artery disease complicated with renal dysfunction

目的探讨阿托伐他汀对冠心病患者肾功能不全的治疗作用。方法回顾性分析2002年1月～2004年1月间我院冠心病合并肾功能不全患者,按是否长期接受阿托伐他汀(lipitor每天40mg),分为阿托伐他汀组46例,男31例,女15例,年龄(52±10)岁,长期接受阿托伐他汀40mg/d治疗;对照组61例,男37例,女24例,年龄(53±11)岁,未曾接受他汀类药物治疗。在2006年3～4月间随访,总随访时间26～50(38±8)个月,观察心血管事件和肾功能。结果阿托伐他汀组血清尿素氮由(11.2±3.0)mmol/L降到(7.6±2.0)mmol/L(P<0.001);血清肌酐由(162±26!mol/L降到121±30!mol/L(P<0.001),54%的患者血清肌酐恢复正常。但对照组并无明显改善(P>0.05)。结论冠心病合并肾功能不全的中国人,长期接受阿托伐他汀40mg/d治疗,能改善肾功能。

Objectives To assess the safety and effects of atorvastatin 40mg qd on serum hpids, renal function and clinical events in patients with coronary artery disease （CAD） complicated with renal dysfunction. Methods From January 2002 to January 2004, 107 patients with coronary artery disease （CAD） complicated with renal dysfunction were divided into two group： 61（male 37 and female 24） were controls and 46（male 31 and female 15）were prescribed 40 rag/day of atorvastatin. Average age （53.58± 11.27）.The follow-up time was 26-50 month. The investigative data included the cardiovascular events and renal function. Results There was also a significant（P〈0.0001） fall in serum creatinine from （162.1± 25.9）μmol/L to （121.4±29.9）μmol/L. And there were no detectable changes in control group （P〉0.05）. The follow-up period,the serum creatinine was turned to normal in 54.3% patients of treatment group. Conclusions For the patients with coronary artery disease （CAD）complicated with renal dysfunction in China,a long-term treatment of atorvastatin 40 mg/d can improve the renal function. Further studies are required to identify the mechanisms involved in this phenomenon.