雷公藤内酯醇洗脱支架对冠状动脉支架内再狭窄的影响

The effect of triptolide-eluting stent on coronary artery in-stent restenosis

目的研究雷公藤内酯醇洗脱支架预防冠状动脉支架植入术后再狭窄的有效性及安全性。方法杂种幼猪20只,分别植入雷公藤内酯醇洗脱支架和普通裸金属支架各10枚。术后28d比较两组的冠状动脉造影形态、组织病理及血生化结果。结果支架部位血管腔面积裸支架组小于雷公藤内酯醇组(P<0.05)、支架内增生内膜面积及内膜增生程度裸支架组大于雷公藤内酯醇组(P<0.05)。未发现明显毒副作用。结论雷公藤内酯醇洗脱支架能抑制新生内膜的形成,在支架植入后4周能预防再狭窄的形成。

Objectives Triptolide-eluting stents were implanted in pig coronary arteries to investigate the effectiveness and safety in the prevention of restenosis. Methods Ten triptolide-eluting stents and ten stainless steel stents were implanted in twenty pigs coronary arteries randomized. 28 days later, arteries were compared in angiography, histopathology and histomorphometry analysis. Results The lumen areas of control group were much smaller than those of triptolide group（P〈0.05）. The neointimal areas and lumen stenosis rates in control group were larger than those in triptolide group （P〈0.01）. The side effect were not found in experiment animals. Conclusions The triptolide-eluting stent is effective in inhibiting of neointimal formation. It can prevent restenosis in a porcine coronary artery restenosis model within 4 weeks.