2型糖尿病并发症的病例对照研究

An epidemic factor research on the complication of type 2 diabetes mellitus

目的探讨2型糖尿病并发症的流行病学病因。方法根据1997年“美国糖尿病协会糖尿病诊断标准”,于2003年1月至2005年1月,在攀枝花19冶职工医院,按性别和年龄1:1配对收集有并发症的2型糖尿病患者(病例组)和无并发症的2型糖尿病患者(对照组)121对,调查确诊前后和确诊时的暴露情况,资料采用Logistic回归分析。结果进入多因素Logistic回归方程的变量为:2型糖尿病发病后的食用油(Bi=2.109,OR=8.240),确诊血糖值(Bi=1.325,OR=3.762),发病前饮酒(Bi=1.124,OR=3.077),2型糖尿病的发病年龄(Bi=-1.953,OR=0.050),发病后使用胰岛素(Bi=-1.611,OR=0.200),以及发病后经常得到亲戚朋友的关心照顾(Bi=-0.918,OR=0.399)。结论发病后食用动物油、确诊时的血糖水平、发病前饮酒是2型糖尿病并发症的危险因素,而发病年龄、发病后使用胰岛素、经常得到亲朋好友的关心照顾是2型糖尿病的保护因素。

Objective To investigate the risk of the complication of type 2 diabetes mellitus. Methods 242 subjects were selected in the study. 121 cases （type 2 diabetes mellitus with complications） and 121 age-sex-matched controls （type 2 diabetes mellitus without complications） were diagnosed according to ＂ADA diabetes mellitus criteria＂ （ 1997）. Conditional Logistic regression analysis was used for data analysis. Results Six variables in the Logistic regression equation were （ 1 ） edible oil after affection of type 2 diabetes mellitus （ Bi = 2. 109, OR = 8. 240）, （2） the value of blood sugar when type 2 diabetes mellitus diagnosed （Bi = 1. 325, OR = 3.762）, （3） drinking before type 2 diabetes mellitus （Bi = 1. 124, OR = 3.077）, （4） age when affected by type 2 diabetes mellitus （Bi = - 1. 953, OR =0.142）, （5） usage of insulin （Bi = -1.611,OR = 0.200）, （6） more cares from the patients＇ relatives and friends after affection （Bi = - 0. 918, OR = 0. 399）. Conclusion It suggests that animal oil, high blood sugar value when type 2 diabetes mellitus diagnosed and drinking before type 2 diabetes mellitus are the risk actors of the complications of type 2 diabetes mellitus. However, incidence age of type 2 diabetes mellitus, after type 2 diabetes mellitus, usage of insulin and more cares from the patients＇ relatives and friends are protective factors.