南宁市569例孕妇和194例新生儿巨细胞病毒感染血清学调查

Serology of HCMV infecion of 569 Pregnant women and 194 Infants in Nanning in Guangxi.

用ＥＬＩＳＡ检测５６９份孕妇血清及１９４份新生儿脐带血ＨＣＭＶ抗体ＩｇＧ及ＩｇＭ。孕妇ＨＣＭＶＩｇＧ及ＩｇＭ阳性率分别为９５．８％与３．１％，说明孕妇普遍感染过ＨＣＭＶ，在妊娠期间可发生活动性感染。新生儿脐带血ＨＣＭＶＩｇＧ及ＩｇＭ阳性率分别为９４．７％和１．４％，提示有先天性ＨＣＭＶ感染产生。母婴配对检测结果表明有活动性感染的孕妇分娩的新生儿不一定发生先天性感染，一次母血ＨＣＭＶＩｇＭ检测阴性的新生儿也可发生先天性ＨＣＭＶ感染。

Anti-HCMV IgG and IgM from blood samples of 569 pregnant Women and 194 infants' umbillcal cords were detected by ELISA. Positive rstes of Anti-IgG and IgM from pregnant women were 95.8% and 3.1%, respectively. The results showed that prevalence was common and active infection occurred during pregnancy. Positive rstes of Anti-IgG and IgM from newborn infants were 94.7% and 1.4%, respectively. This suggested that congenital infection occured. Newborn infants whose mothers had active infection might suffer from congenital infection. Newborn infants from anti-HCMV IgM negative mother detected only once also had congenital infection. The maternal blood, therefore, has to be detected more times for anti-HCMV IgM.