涎腺腺样囊性癌高转移细胞克隆株Acc－M体外移动性和粘附性的实验观察

COMPARATIVE STUDY OF IN VITRO MOTILITY AND ADHESION OF HIGH AND LOW METASTATIC SALIVARY ADENOID CYSTIC CARCINOMA CELL

研究癌细胞的运动性和粘附性，是探索恶性肿瘤侵袭转移机理的重要方面。本研究应用改良的Ｂｏｙｄｅｎ小室测得涎腺腺样囊性癌细胞系Ａｃｃ－２和高转移细胞株Ａｃｃ－Ｍ的体外运动能力，经统计学处理，高转移细胞株的运动能力明显高于Ａｃｃ－２系细胞株；两种细胞克隆的体外粘附性也有较大的差别，说明在Ａｃｃ转移过程中。

tudying the in vitro motility and adhesion of tumor cell is important in understanding the invasion and metastasis mechanisms of malignant tumors.The in vitro motility of two Acc cell lines, hiqh metastatic Acc-M, strain,and Acc-2 line,was measured by Boyden chamber technique.Statistical analysis of the results showed slgnficant differences between the high and low metastatic cells.The ability of motility was higher in Acc-M than that in Acc-2. The cell adhesion test showed that Acc-M had stronger ability of adhesion than Acc-2.The result suggested in vitro motility and adhesion may play an important role in invasion and metastasis of Acc.