益气活血法对缺血性脑卒中急性期(气虚血瘀证)神经保护作用的影响

The Influence of Yiqi Huoxue Method for Protecting Nerve in Acute Stage of Ischemic Stroke (Qi-Deficiency and Blood-Stasis Syndrome )

目的:观察益气活血法对缺血性脑卒中急性期(气虚血瘀证)的神经保护作用。方法:将42例缺血性脑卒中急性期患者随机分为2组。对照组21例,予常规西药治疗;治疗组21例,在对照组治疗基础上加用黄芪注射液和灯盏细辛注射液。疗程均为3天。观察治疗前后血清白介素-6(IL-6)、血白细胞总数(WBC)、中性粒细胞比值(NE％)、神经功能缺损评分(NIHSS)及证候积分的变化。结果:治疗后2组IL-6、WBC、NE％均较治疗前下降,与治疗前比较,差异均有显著性意义(P<0．05);治疗组与对照组治疗后比较,差异均有显著性意义(P<0．05),提示治疗组下降幅度大于对照组。治疗后2组NIHSS均增高,但治疗组增高幅度小于对照组(P<0．05)。治疗后2组证候积分均明显下降,与治疗前比较,差异均有显著性意义(P<0．05);治疗组与对照组治疗后比较,差异有显著性意义(P<0．05),提示治疗组下降幅度大于对照组。结论:益气活血法能抑制缺血性脑卒中急性期炎症反应,改善中风患者临床症状,有利于急性缺血性脑血管病患者神经功能的恢复,是治疗缺血性脑卒中急性期脑损伤的有效方法之一。

Objective: To observe nerve protection of acute stage of is-chemic stroke (AIS) of qi-deficiency and blood-stasis syndrome by Yiqi Huoxue method (YHM). Methods: 42 cases of acute stage of AIS were allocated to 2 groups randomly. The control group (21 cases) was treated by routine western medicine; the treatment group (21 cases) added with Injection Astragali (黄芪注射液) and Injection Erigeronis Breviscapi(灯盏细辛注射液). Three days constituted the course of treatment. The serum interleukin-6 (IL-6), count of white blood cell (WBC), ratio of neu-trophil (NE% ), scoring of nervous function impairment and changes of scoring of syndrome pattern were observed before and after treatment. Re-sults: After treatment, IL - 6, WBC and NE% were decreased than that of before treatment ( P < 0. 05); the comparison of treatment group and control group after treatment showed marked significance ( P < 0. 05), it is indicated that the decrease range is more than control group. After treatment, the scoring of nervous function impairment was increased in both groups but the increase range of treatment group is smaller than control group ( P < 0. 05) . After treatment, the scoring of syndrome pattern was markedly decreased, comparison with before treatment showed marked significance ( P < 0. 05). After treatment, the comparison of treatment group and control group showed marked significance (P < 0. 05), it is indicated that the decrease range is more than control group. Conclusion: YHM can inhibit the inflammatory reaction of AIS, improve clinical symptoms, recover the nervous function, and is an effective therapy for AIS.