大连市169例出生缺陷的发生率及病因分析

Analysis of tefatogenic factors of mlalformed neonates with 169 cases.

本文将我院92年3月至94年2月出生缺陷儿169例监测材料进行总结.出生缺陷儿占同期出生围产儿1596O人的1.06%.其中男性97人,女性72人,男女之比为1,35:1.骨骼肌肉系统畸形占25.44%,为首位.依次为泌尿生殖系统18.93%,面、耳和颈部16.57%,心血管系统8.86%,消化系统7.11%等.我院于92年3月至94年2月二年间围产围儿死亡率为12.1%,出生缺陷儿死亡率为26.14%,二者经统计学处理P<0.01,有显著差异.可见出生畸形儿目前已成为新生儿主要死亡原因.出生畸形儿死因中.中枢神经系统占首位(44.19%),依次为心血管系统(18.60%),消化系统(16.28%),骨骼系统(11.63%)等.并讨论了出生畸形儿的病因.

This paper review monitoring data of malformed neonates birthed between 1992. 3 and 1994; 2. The 169 malformed neonates account for 1. 06% of 15960 perinatal neonates at the same time. The proportion of male 97 and fimale 72 is 1. 35:1. The deformity of skeletal muscles system (25. 44% ) is first, followed by genitourinary sys-tem(L8. 93%),face, ear and neck(16. 57%),car. diovascular system(8. 86%)and alimentary system: (7. 11%). The perinatal and deformity mortality are 1. 21%. 26. 14% relatively between 1992. 3 and 1994. 2. There is significative difference,P< 0. 01. This suggest that deformity have become the primary carses of neonatal death, of which the ' central nervous system is first (44. 19%),followed by cardiovascular system(18. 60%)alimentary sys-tem(16,28%),skeletal muscles system(11.63%). The etiology of deformity,include geneted and environmental factors. Through the analysis of environmental factors, the authors propose the approaches that reduce deformity development to help orthogenics.