高频超声评价高血压患者血管内皮功能探讨

Investigation of Endothelial Function in Hypertension Using High-frequency Ultrasonography.

目的探讨高血压对血管内皮功能的影响。方法应用高频超声检测35例原发性高血压患者和35例血压正常的健康人在静息状态、反应性充血后以及舌下含服硝酸甘油后的肱动脉内径变化。结果原发性高血压患者反应性充血引起肱动脉内径扩张显著低于血压正常的健康人（7．11±604）％，S（13．83±4．32）％，P〈0．01，舌下含服硝酸甘油引起肱动脉内径扩张无显著性差别（17．16±3．32）％VS（18．69±5．25）％，P〉0．05。结论原发性高血压患者存在血管内皮依赖性舒张功能爱损，高频超声是评价血管内皮功能的无创，简单，可靠的方法。

Objective To investigate the relationship between hypertension and endothelial vasodilatation function, Methods High-frequency ultrasonography was applied to measure the changes of brachial artery diameter during rest, reactive hyperemia and after sublingual glyceryl trinitrate in 35 patients with mild to moderate essential hypertension and 35 normotensive healthy volunteers, Results There was significant difference of vessel diameter changes in hypertension group and control group with reactive hyperaemia [（7.11±6.04）% vs （13.83±4,32）%, P〈0.01], but no significant difference alter sublingual glyceryl trinitrate[（17.16±3.32）% vs （18.69 ± 5.25）%,P〉0.05].Conclusion Abnormal endothelial function exists in hypertension patients. High-frequency ultrasonography is simple, invasive, and accurate in evaluation endothelial function.