孤独症患者T淋巴细胞功能及其亚群的研究

AstudyofTlymphocytefunctionandT┐celsubsetsinpatientswithautism

为研究孤独症患者免疫学方面的异常，探索孤独症的病理学机制，对２７例孤独症、１６例精神发育迟滞（ＭＲ）和１８名正常儿童进行了Ｔ淋巴细胞增殖反应及其亚群的测定，应用ｔ检验进行统计学处理。结果显示：孤独症组的ＣＤ４阳性细胞百分数明显低于其它两组（ｔ值分别为２．６４，２．２１；Ｐ平均值＜０．０５），孤独症ＣＤ３阳性细胞也较ＭＲ组显著为低（ｔ＝２．４７４，Ｐ＜０．０２）。在淋巴细胞增殖反应方面，孤独症组也较对照组明显降低（ｔ＝２．１７５，Ｐ＜０．０５）。提示ＣＤ４阳性细胞数下降与孤独症的发病有关。

Autismisachildhoodmentaldisorder.Itsetiologyhadnotbeenascertained.Toexploretheautisticpathologicalmechanism,thepossibleimmuneabnormalitieswerestudied.Among27autisticchildren,16childrenwithmentalretardation(MR)and18normalchildren,wecomparedthediferentTlymphocyteproliferativeresponsesandthesubsetsofTlymphocytes.Thedatawereanalyzedwiththestudent'st-test.TheresultsshowedthattheautisticsubjectshadasingnificantlylowerpercentageofCD+4celsthanthatinthementalretardationandthenormalsubjects(t=2.64and2.21respectory,P<0.05),andalowerpercentageofCD+3.CelsthanthatintheMRsubjects(t=2.474,P<0.02);Mitogen-inducedproliferationtophytohemagglutininpatients.withautismhadasignificantlylowerratethaninnormalsubjects(t=2.175,P<0.05).OurresultssuggestedthatadecreaseinCD+4celswasassociatedwithautism.TherelationsbetweentheautismandtheTlymphocytefunctionwerediscussed.