慢性肾衰竭患者尿乙酰氨基葡萄糖苷酶活性检测的临床意义

Analysis of urinary acetylglucosaminidase in glomerulonephritis patients with chronic renal failure

目的:探讨慢性肾衰竭患者尿乙酰氨基葡萄糖苷酶(N-acetylβ--D-glucosam in idase,NAG)活性变化及其在慢性肾衰竭进展过程中的意义。方法:用光电比色法测定87例慢性肾衰竭患者尿NAG的活性,并根据其肾脏病变是否稳定以及是否合并高血压将患者分为肾脏病变稳定组、肾脏病变活动组、高血压组和非高血压组,分别比较尿NAG的活性。同期选择30名健康人作为对照组。结果:慢性肾衰竭尿NAG活性显著高于对照组(P<0.01),肾脏病变活动组尿NAG活性显著高于肾脏病变稳定组(P<0.01),高血压组尿NAG活性显著高于非高血压组(P<0.01)。结论:慢性肾衰竭病程中,肾脏病变活动和高血压可能是加重肾小管-间质损伤的重要因素。

Objectlve：To study the changes of the level of urinary acetylglucosaminidase （ N-acetyl-β-D-glucosaminidase, NAG ） in patients with chronic renal failure（CRF） and its clinical significance in the development of CRF. Methods：Eight-seven patients were divided into 2 groups according to the stability of the disease and the level of blood pressure; and thirty healthy persons acted as controls. Their NAG activity was measured by colorimetry test and compared. Results：The urinary NAG level in CRF patients was significandy higher than that of the controls（ P 〈0.01 ）. The urinary NAG level in patients with unstable CRF was significantly higher than that in patients with stable CRF（ P 〈 0.01 ）, and the urinary NAG level of CRF patients with hypertension was higher than that of patients without hypertension（ P 〈0.01 ）. Conclusions ： The instability of CRF and hypertension may be pivotal factors that aggravate tubulointerstital injury.