丙泊酚和一氧化氮用于无痛人工流产的临床效果比较

Effect of propofol and nitric oxide on painless induced abortion

目的:比较丙泊酚静脉麻醉和一氧化氮吸入用于无痛人工流产术的镇痛效果。方法:将200例要求施行人工流产术的早孕妇女随机分为丙泊酚组(观察组):采用丙泊酚联合小剂量芬太尼在静脉麻醉下实施人工流产术中镇痛;一氧化氮组(对照组):采用50%一氧化氮与50%氧气为混合气体吸入实施人工流产术镇痛。观察两组的镇痛作用、宫口松弛情况、人工流产综合征发生率及出血情况及离床时间。结果:丙泊酚和一氧化氮均有良好的镇痛作用和宫口松弛作用,但丙泊酚的镇痛和宫口松弛作用均明显高于一氧化氮(P<0.005)。两组综合征发生率和术中出血量均无明显不同(P>0.05),而观察组离床时间明显长于对照组(P<0.001)。结论:丙泊酚和一氧化氮用于人工流产镇痛均有良好效果,丙泊酚镇痛效果优于一氧化氮。

Objective： To compare the analgesic effects of propofol and nitric oxide on painless artificial abortion. Methods：Two hundred women with early pregnancy were randomly divided into two groups. Propofol combined with a little fentanyl was used in the observation group while 50% nitric oxide combined with 50% oxygen was used in the control group. The effects of analgesia,cervix relaxation, the occurrence of artificial abortion syndrome and bleeding during the operation were observed. Results： Both propofol and nitric oxide had good effect of analgesia and cervix relaxation. Propofol had a better effect than nitric oxide in artificial abortion （ P 〈 0. 05 ）. There was no significant difference in the occurrence of artificial abortion syndrome and the quantity of bleeding between the two groups（P 〉0.05）. The time of the mobilization of the patients in the observation group is significantly later than that in the control group（P 〈0. 001 ）. Conclusions： Both propofol and nitric oxide have a good effect of analgesia in the induced abortion. Propofol is better than nitric oxide.