急性酒精中毒患者血浆LPO、血清PLA_2和红细胞SOD测定的临床意义

The Clinic Significance of LPO SOD and PLA_2 Assessment in Blood of Patients with Acute Alcoholism

对比观察１２例急性酒精中毒患者与１５例健康人的血浆脂质过氧化物（ＬＰＯ）水平、血清磷脂酶Ａ２（ＰＬＡ２）和红细胞超氧化物歧化酶（ＳＯＤ）活性，发现患者的ＬＰＯ水平和ＰＬＡ２活性明显高于对照组，ＳＯＤ活性明显低于对照组，差别有显著性意义（Ｐ＜０．０５），ＬＰＯ水平与ＳＯＤ活性呈显著负相关（ｒ＝－０．５２６６、Ｐ＜０．０１），结果提示：急性酒精中毒患者体内氧化作用增强，抗氧化作用降低，有氧化－抗氧化作用的失衡；有组织细胞的损伤；致损伤因素ＬＰＯ和ＰＬＡ２共同介入了急性酒精中毒的发病过程。

Detecting the plasma level of lipid peroxid (LPO),activities of serum phospholipase A2(PLA2) and superoxide dismutase(SOD)in red blood cells in 12 patients with acute alcoholism and in 15 normal controls.We found that the of LPO and the activity of PLA2 were higher and activity of SOD was lower than that of the control.There waS significant difference between the patients and the controls(P<0.05).Negative corelation between the activity of SOD and the level of LPO was observed (r=0.5266 P<0.01).The results indicated that the metebolic oxidation process was increased and the anti-oxidation process was decreased in patients with acute alcoholism. There is unbalance of the oxidation and the anti-oxidation process.LPO and PLA2might play a harmful role in the pathogenesis of acute alcoholism