E-钙粘素和CD_(44)V6表达与食管癌预后的关系

Relationship of E-cadherin and CD_(44)V6 expression and prognosis in esophageal carcinoma

目的探讨E-钙粘素(E-CD)、CD44V6表达与食管癌患者临床病理及预后的关系。方法对58例食管鳞癌患者术后标本和25例正常食癌组织应用SP法检测E-CD和CD44V6的表达,对其中42例进行了术后3年随访。结果E-CD阳性表达率与食管鳞癌患者癌细胞浸润深度、淋巴结转移显著有关(P<0.01),与食管癌细胞分化程度、临床分期有关(P<0.05),E-CD表达阳性组1、2和3年生存率分别为94.12%、88.24%和58.82%,阴性组分别为83.81%、56.00%和12.00%(P<0.01);CD44V6阳性表达率与食管鳞癌细胞分化程度无关(P>0.05),与食管鳞癌患者细胞浸润深度、淋巴结转移显著有关(P<0.01),与食管鳞癌患者临床分期有关(P<0.05),CD44V6表达阳性存活率1、2和3年生存率分别为83.33%、60.00%和16.67%,阴性组分别为100%、91.67%和66.68%(P<0.01)。结论E-CD和CD44V6表达与食管癌转移、预后密切相关,且该两项指标表达方式相反;当E-CD阴性、,CD44V6阳性时,可能说明患者预后差,有转移可能。

[Objective] To study the of E-CD and CD44V6 expression with the clinical pathological features and prognosis in esophageal carcinoma. [Methods] E-CD and CD44V6 expression were evaluated in the tissues of 58 human esophageal carcinomas and 25 normal esophageal mucosa by using immunohistochemical SP method. 42 cases were followed up for 3 years. [Results] The expression of E-cadherin was significiantly related to the invasion depth and lymph node metastasis, cell differentiation degree and clinical stage of the tumors. （P 〈0.01, P 〈0.05）. Survival rate of the first year, the second year, the third year were 94.12%, 88.24%, 58.82% respectively in positive E-cadherin expression, that were 83.81%, 56.00%, 12.00% in negative expression （P 〈0.01）. The expression of CD44V6 was related to the invasion depth and lymph node metastasis, clinical stage of the tumors （P 〈0.01, P 〈0.05）, but not related to the cell differentiation degree（P 〉0.05）. Survival rate of the first year, the second year, the third year were 83.33%, 60.00%, 16.67% in positive CD44V6 expression, that are 100%, 91.67%, 66.68% in negative ex- pression （P 〈0.01）. [Conclusions] E-CD and CD44V6 expression are correlated with metastasis and prognosis in esophageal tumors. The patients would have bad prognosis and metastasis when E-cadherin expression was positive and CD44V6 expression was negative.